The gestational diabetes mellitus is defined as disorder of glucose tolerance that is first detected during pregnancy. The purpose of the study was to investigate course and outcomes of pregnancy in pregnant women with gestational diabetes mellitus over 10 years. The analysis of course of pregnancy, childbirth and condition of newborns of 2363 women with gestational diabetes mellitus, observed in Ivanovo antenatal clinics in 2014–2023, was carried out. The analysis established increasing of rate of such complications as threatened early miscarriage, threatened late miscarriage, cervical insufficiency, toxicosis of pregnancy, anemia, chronic arterial hypertension, gestational arterial hypertension, moderate and severe preeclampsia, eclampsia, placental insufficiency, fetal growth restriction syndrome, chronic intrauterine fetal hypoxia, polyhydramnios, intrauterine fetal death, placenta previa, premature separation of normally located placenta, diabetic fetopathy. The childbirth was complicated by prenatal rupture of amniotic fluid, weakness of labor, dis-coordination of labor, clinically narrow pelvis, shoulder dystocia, and operative delivery. In newborns, congenital malformations, renal pyelectasia, and respiratory distress syndrome were diagnosed. The connecting-link between organism of mother and developing fetus is placenta. The various changes affecting maternal organism, including hyperglycemia, continue in formation of adverse events especially in placenta and subsequent development of negative complications and outcomes of pregnancy.

gestational diabetes mellitus, course of pregnancy, perinatal outcomes.