Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot246710.32687/0869-866X-2025-33-6-1414-1419Научная статьяThe Characteristics of Course of Pregnancy and Perinatal Outcomes in Women with Gestation Diabetes Mellitus (The Results of Ten-Years Research)BatrakN. V.IvanovaI. V.The Federal State Budget Educational Institution of Higher Education “The Ivanovo State Medical University” of the Minzdrav of Russia, 153012, Ivanovo, Russia151220253361414141919122025Copyright © 2025,2025The gestational diabetes mellitus is defined as disorder of glucose tolerance that is first detected during pregnancy. The purpose of the study was to investigate course and outcomes of pregnancy in pregnant women with gestational diabetes mellitus over 10 years. The analysis of course of pregnancy, childbirth and condition of newborns of 2363 women with gestational diabetes mellitus, observed in Ivanovo antenatal clinics in 2014–2023, was carried out. The analysis established increasing of rate of such complications as threatened early miscarriage, threatened late miscarriage, cervical insufficiency, toxicosis of pregnancy, anemia, chronic arterial hypertension, gestational arterial hypertension, moderate and severe preeclampsia, eclampsia, placental insufficiency, fetal growth restriction syndrome, chronic intrauterine fetal hypoxia, polyhydramnios, intrauterine fetal death, placenta previa, premature separation of normally located placenta, diabetic fetopathy. The childbirth was complicated by prenatal rupture of amniotic fluid, weakness of labor, dis-coordination of labor, clinically narrow pelvis, shoulder dystocia, and operative delivery. In newborns, congenital malformations, renal pyelectasia, and respiratory distress syndrome were diagnosed. The connecting-link between organism of mother and developing fetus is placenta. The various changes affecting maternal organism, including hyperglycemia, continue in formation of adverse events especially in placenta and subsequent development of negative complications and outcomes of pregnancy.gestational diabetes mellituscourse of pregnancyperinatal outcomesгестационный сахарный диабеттечение беременностиперинатальные исходы[Lee J., Lee N. K., Moon J. H. Gestational Diabetes Mellitus: Mechanisms Underlying Maternal and Fetal Complications. Endocrinol. Metab. (Seoul). 2025;40(1):10—25. doi: 10.3803/EnM.2024.2264][Kim K. S., Hong S., Han K., Park C. Y. The clinical characteristics of gestational diabetes mellitus in Korea: a national health information database study. Endocrinol Metab (Seoul). 2021;36:628—36. doi: 10.3803/EnM.2020.948][Wang H., Li N., Chivese T., Werfalli M., Sun H., Yuen L. IDF Diabetes Atlas: estimation of global and regional gestational diabetes mellitus prevalence for 2021 by international association of diabetes in pregnancy study group’s criteria. Diabetes Res. Clin. Pract. 2022;183:109050. doi: 10.1016/j.diabres.2021.109050][Moon J. H., Jang H. C. Gestational diabetes mellitus: diagnostic approaches and maternal-offspring complications. Diabetes Metab. J. 2022;46:3—14. doi: 10.4093/dmj.2021.0335][Won S., Kim H., Park J., Oh K., Choi S., Jang H. Quality of life in women with gestational diabetes mellitus and treatment satisfaction upon intermittently scanned continuous glucose monitoring. J Korean Med. Sci. 2025;40:e46. doi: 10.3346/jkms.2025.40.e46][Chung H. R., Moon J. H., Lim J. S., Lee Y. A., Shin C. H., Hong J. S., et al. Maternal hyperglycemia during pregnancy increases adiposity of offspring. Diabetes Metab. J. 2021;45:730—8. doi: 10.4093/dmj.2020.0154][Aldahmash W. M., Alwasel S. H., Aljerian K. Gestational diabetes mellitus induces placental vasculopathies. Environ. Sci. Pollut. Res. Int. 2022;29(13):19860—8. doi: 10.1007/s11356-021-17267-y][Owen M. D., Kennedy M. G., Quilang R. C., Scott E. M., Forbes K. The role of microRNAs in pregnancies complicated by maternal diabetes. Clin Sci (Lond). 2024;138(18):1179—207. doi: 10.1042/CS20230681][Pan X., Jin X., Wang J., Hu Q., Dai B. Placenta inflammation is closely associated with gestational diabetes mellitus. Am. J. Transl. Res. 2021;13(5):4068—79.][Fisher J. J., Vanderpeet C. L., Bartho L. A., McKeating D. R., Cuffe J. S. M., Holland O. J., et al. Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus. J. Physiol. 2021;599(4):1291—305. doi: 10.1113/JP280593][Nguyen-Ngo C., Jayabalan N., Haghvirdizadeh P., Salomon C., Lamppas M. Role of adipose tissue in regulating fetal growth in gestational diabetes mellitus. Placenta. 2020;102:39—48. doi: 10.1016/j.placent.2020.05.006][Kim W., Park S. K., Kim Y. L. Fetal abdominal obesity detected at 24 to 28 weeks of gestation persists until delivery despite management of gestational diabetes mellitus. Diabetes Metab. J. 2021;45:547—57. doi: 10.4093/dmj.2020.0078][Moon J. H., Won S., Won H., Son H., Oh T. J., Kwak S. H. Metabolic Phenotypes of Women with Gestational Diabetes Mellitus Affect the Risk of Adverse Pregnancy Outcomes. Endocrinol. Metab. (Seoul). 2025;40(2):247—57. doi: 10.3803/EnM.2024.2089][Immanuel J., Simmons D., Harreiter J., Desoye G., Corcoy R., Adelantado J. M., et al. Metabolic phenotypes of early gestational diabetes mellitus and their association with adverse pregnancy outcomes. Diabet Med. 2021;38:e14413. doi: 10.1111/dme.14413][Wang N., Song L., Sun B., Peng Y., Fei S., Cui J. Contribution of gestational diabetes mellitus heterogeneity and prepregnancy body mass index to large-for-gestational-age infants: a retrospective case-control study. J. Diabetes. 2021;13:307—17. doi: 10.1111/1753-0407.13113][Yang F., Liu H., Ding C. Gestational diabetes mellitus and risk of neonatal respiratory distress syndrome: a systematic review and meta-analysis. Diabetol. Metab. Syndr. 2024;16(1):294. doi: 10.1186/s13098-024-01539-x][Yildiz Atar H., Baatz J. E., Ryan R. M. Molecular Mechanisms of Maternal Diabetes Effects on Fetal and Neonatal Surfactant. Children (Basel). 2021;8(4):281. doi: 10.3390/children8040281][Saucedo R., Ortega-Camarillo C., Ferreira-Hermosillo A., Díaz-Velázquez M. F., Meixueiro-Calderón C., Valencia-Ortega J. Role of oxidative stress and inflammation in gestational diabetes mellitus. Antioxidants. 2023;12(10):1812. doi: 10.3390/antiox12101812][Fasoulakis Z., Koutras A., Antsaklis P., Theodora M., Valsamaki A., Daskalakis G. Intrauterine Growth Restriction Due to Gestational Diabetes: From Pathophysiology to Diagnosis and Management. Medicina (Kaunas). 2023;59(6):1139. doi: 10.3390/medicina59061139][Zhang L., Li K., Tian S., Wang X.-Q., Li J.-H., Dong Y.-C., et al. Down-regulation of microRNA-30d-5p is associated with gestational diabetes mellitus by targeting RAB8A. J. Diabetes Compl. 2021;35(8):107959. doi: 10.1016/j.jdiacomp.2021.107959][Shah K. B., Chernausek S. D., Teague A. M., Bard D. E., Tryggestad J. B. Maternal diabetes alters microRNA expression in fetal exosomes, human umbilical vein endothelial cells and placenta. Pediatr. Res. 2021;89:1157—63. doi: 10.1038/s41390-020-1060-x][Chen X., Yang F., Zhang T., Wang W., Xi W., Li Y., et al. MiR-9 promotes tumorigenesis and angiogenesis and is activated by MYC and OCT4 in human glioma. J. Exp. Clin. Cancer Res. 2019;38:99. doi: 10.1186/s13046-019-1078-2][Li W., Yuan X., He X., Yang L., Wu Y., Deng X., The downregulation of miR-22 and miR-372 may contribute to gestational diabetes mellitus through regulating glucose metabolism via the PI3K/AKT/GLUT4 pathway. J. Clin. Lab. Anal. 2022;36(7):e24557. doi: 10.1002/jcla.24557][Hou L. J., Han J. J., Liu Y. Up-regulation of microRNA-503 by high glucose reduces the migration and proliferation but promotes the apoptosis of human umbilical vein endothelial cells by inhibiting the expression of insulin-like growth factor-1 receptor. Eur. Rev. Med. Pharmacol. Sci. 2018;22(11):3515—23. doi: 10.26355/eurrev_201806_15178][Joshi N. P., Mane A. R., Sahay A. S., Sundrani D. P., Joshi S. R., Yajnik C. S. Role of Placental Glucose Transporters in Determining Fetal Growth. Reprod Sci. 2022;29(10):2744—59. doi: 10.1007/s43032-021-00699-9][Napso T., Zhao X., Lligona M. I., Sandovici I., Kay R. G., George A. L., et al. Placental secretome characterization identifies candidates for pregnancy complications. Commun. Biol. 2021;4:701. doi: 10.1038/s42003-021-02214-x][Yang Y., Guo F., Peng Y., Chen R., Zhou W., Wang H. Transcriptomic profiling of human placenta in gestational diabetes mellitus at the single-cell level. Front. Endocrinol (Lausanne). 2021;12:679582. doi: 10.3389/fendo.2021.679582][Jiao B., Wang Y., Li S., Lu J., Liu J., Xia J., et al. Dissecting human placental cells heterogeneity in preeclampsia and gestational diabetes using single-cell sequencing. Mol. Immunol. 2023;161:104—18. doi: 10.1016/j.molimm.2023.07.005][El Hajj N., Pliushch G., Schneider E., Dittrich M., Muller T., Korenkov M. Metabolic programming of MEST DNA methylation by intrauterine exposure to gestational diabetes mellitus. Diabetes. 2013;62:1320—8. doi: 10.2337/db12-0289][Xie Y., Zhou W., Tao X., Lv H., Cheng Z. Early gestational blood markers to predict preeclampsia complicating gestational diabetes mellitus. Diabetes Metab. Syndr. Obes. 2023;16:1493—503. doi: 10.2147/DMSO.S410912]