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MALIGNANT NEOPLASMS OF THE REPRODUCTIVE SYSTEM IN MEN AND THEIR CONNECTION WITH THE HUMAN PAPILLOMAVIRUS. (REVIEW)
- Authors: Gvasalia B.R.1,2,3, Stroganov R.V.1,2,4, Avanesyan I.O.1,2, Krupatkin I.A.1,2, Isaeva A.V.1,2
- Affiliations:
- RosUniMed, 127006, Moscow, Russia
- Moscow Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), 125080, Moscow, Russia
- Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department, 115184, Moscow, Russia
- Issue: Vol 32 (2024): NO ()
- Pages: 1090-1093
- Section: Articles
- URL: https://journal-nriph.ru/journal/article/view/1779
- DOI: https://doi.org/10.32687/0869-866X-2024-32-s2-1090-1093
- Cite item
Abstract
The issue of malignant tumor occurrence associated with viral infections is a particularly significant one. Approximately 15—20% of tumors have some connection with various viral infections. An extensive amount of data has been gathered on neoplasms of the female reproductive system linked to the human papillomavirus (HPV). However, the connection between papillomavirus infection and malignant neoplasms in the male reproductive system requires further investigation. The aim of this review is to examine the association between malignant neoplasms of the male reproductive system and HPV, as well as to consider the issue of male vaccination. A research team conducted a literature review on the topic using databases such as the National Library of Medicine, Web of Science, and CyberLeninka. Data was collected on three types of malignant tumors in the male reproductive system: penile cancer, testicular cancer, and prostate cancer. In the context of the relationship between HPV and penile and prostate cancers, data on the presence of viral DNA in tumor tissue samples have been isolated. A study found that HPV DNA was present in semen samples from 34.9% of patients with testicular cancer, compared to only 2.4% in a control group. However, understanding of the HPV lifecycle raises questions about the link between HPV and testicular cancer. HPV multiplies in dividing epithelial cells, but testicular tissue is of mesodermal origin, and may not provide a suitable environment for HPV reproduction. Based on these findings, it is possible to draw the following conclusions: there are pathogenic reasons for the association between HPV and male reproductive system neoplasms. Further systematic review and meta-analysis are needed to fully understand this complex relationship.
About the authors
B. R. Gvasalia
RosUniMed, 127006, Moscow, Russia; ;Moscow Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), 125080, Moscow, Russia;
R. V. Stroganov
RosUniMed, 127006, Moscow, Russia; ;Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department, 115184, Moscow, Russia
I. O. Avanesyan
RosUniMed, 127006, Moscow, Russia;
I. A. Krupatkin
RosUniMed, 127006, Moscow, Russia;
A. V. Isaeva
RosUniMed, 127006, Moscow, Russia;
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