Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot177910.32687/0869-866X-2024-32-s2-1090-1093Научная статьяMALIGNANT NEOPLASMS OF THE REPRODUCTIVE SYSTEM IN MEN AND THEIR CONNECTION WITH THE HUMAN PAPILLOMAVIRUS. (REVIEW)GvasaliaB. R.StroganovR. V.AvanesyanI. O.KrupatkinI. A.IsaevaA. V.RosUniMed, 127006, Moscow, RussiaMoscow Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH), 125080, Moscow, RussiaResearch Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department, 115184, Moscow, Russia08112024321090109302072025Copyright © 1970,1970The issue of malignant tumor occurrence associated with viral infections is a particularly significant one. Approximately 15—20% of tumors have some connection with various viral infections. An extensive amount of data has been gathered on neoplasms of the female reproductive system linked to the human papillomavirus (HPV). However, the connection between papillomavirus infection and malignant neoplasms in the male reproductive system requires further investigation. The aim of this review is to examine the association between malignant neoplasms of the male reproductive system and HPV, as well as to consider the issue of male vaccination. A research team conducted a literature review on the topic using databases such as the National Library of Medicine, Web of Science, and CyberLeninka. Data was collected on three types of malignant tumors in the male reproductive system: penile cancer, testicular cancer, and prostate cancer. In the context of the relationship between HPV and penile and prostate cancers, data on the presence of viral DNA in tumor tissue samples have been isolated. A study found that HPV DNA was present in semen samples from 34.9% of patients with testicular cancer, compared to only 2.4% in a control group. However, understanding of the HPV lifecycle raises questions about the link between HPV and testicular cancer. HPV multiplies in dividing epithelial cells, but testicular tissue is of mesodermal origin, and may not provide a suitable environment for HPV reproduction. Based on these findings, it is possible to draw the following conclusions: there are pathogenic reasons for the association between HPV and male reproductive system neoplasms. Further systematic review and meta-analysis are needed to fully understand this complex relationship.HPV reviewcancer risk factorpenile cancertesticular cancerprostate cancermale reproductive systemвирус папилломы человекаобзорфактор риска ракарак полового членарак яичкарак простатымужская репродуктивная система[McLaughlin-Drubin M. E., Munger K. Viruses associated with human cancer // Biochim. Biophys. Acta (BBA) Mol. Basis Dis. 2008. Vol. 1782. P. 127—150. DOI: 10.1016/j.bbadis.2007.12.005][Галицкая М. Г., Гайворонская А. Г. Расширение возможностей вакцинопрофилактики папилломавирусной (ВПЧ)-инфекции: защита от целого спектра ВПЧ-ассоциированных заболеваний лиц различного возраста и пола // Педиатрическая фармакология. 2013. Т. 10, №1. С. 13—17.][Martins V. A., Pinho J. D., Teixeira Júnior A. A.L. et al. P16INK4a expression in patients with penile cancer // PLoS One. 2018. Vol. 13, N 10. P. e0205350. DOI: 10.1371/journal.pone.0205350][López-Romero R., Iglesias-Chiesa C., Alatorre B. et al. HPV frequency in penile carcinoma of Mexican patients: important contribution of HPV16 European variant // Int. J. Clin. Exp. Pathol. 2013. Vol. 6, N 7. P. 1409—1415][Kristiansen S., Bjartling C., Torbrand C. et al. Increased prevalence of human papillomavirus in fresh tissue from penile cancers compared to non-malignant penile samples: a case-control study // BMC Cancer. 2022. Vol. 22, N 1. P. 1227. DOI: 10.1186/s12885-022-10324-w][Yu Y. B., Wang Y. H., Yang X. C. et al. The relationship between human papillomavirus and penile cancer over the past decade: a systematic review and meta-analysis // Asian J. Androl. 2019. Vol. 21, N 4. P. 375—380. DOI: 10.4103/aja.aja_39_19][Calmon M. F., Mota M. T., Babeto É. et al. Overexpression of ANXA1 in penile carcinomas positive for high-risk HPVs // PLoS One. 2013. Vol. 8, N 1. P. e53260. DOI: 10.1371/journal.pone.0053260][Garolla A., Pizzol D., Bertoldo A. et al. Testicular cancer and HPV semen infection // Front. Endocrinol. (Lausanne). 2012. Vol. 3. P. 172. DOI: 10.3389/fendo.2012.00172][Зверев В. В., Быкова А. С. Медицинская микробиология, вирусология, иммунология. М.; 2016.][Волгарева Г. М., Ермилова В. Д. Обнаружение онкогена Е7 вируса папилломы человека 18-го типа у больных раком предстательной железы // Российский биотерапевтический журнал. 2019. Т. 18, №1. С. 37—41. doi:10.17650/1726-9784-2019-18-1-37-41][Tsydenova I. A., Ibragimova M. K., Tsyganov M. M. et al. Human papillomavirus and prostate cancer: systematic review and metaanalysis // Sci. Rep. 2023. Vol. 13, N 1. P. 16597. DOI: 10.1038/s41598-023-43767-7][Russo G. I., Calogero A. E., Condorelli R. A. et al. Human papillomavirus and risk of prostate cancer: a systematic review and metaanalysis // Aging Male. 2020. Vol. 23, N 2. P. 132—138. DOI: 10.1080/13685538.2018.1455178][Moghoofei M., Keshavarz M., Ghorbani S. et al. Association between human papillomavirus infection and prostate cancer: A global systematic review and meta-analysis // Asia Pac. J. Clin. Oncol. 2019. Vol. 15, N 5. P. e59—e67. DOI: 10.1111/ajco.13124][Lin Y., Mao Q., Zheng X. et al. Human papillomavirus 16 or 18 infection and prostate cancer risk: a meta-analysis // Ir. J. Med. Sci. 2011. Vol. 180, N 2. P. 497—503. DOI: 10.1007/s11845-011-0692-6][Yang L., Xie S., Feng X. et al. Worldwide prevalence of human papillomavirus and relative risk of prostate cancer: a meta-analysis // Sci. Rep. 2015. Vol. 5. P. 14667. DOI: 10.1038/srep14667][Lawson J. S., Glenn W. K. Evidence for a causal role by human papillomaviruses in prostate cancer — a systematic review // Infect. Agent Cancer. 2020. Vol. 15. P. 41. DOI: 10.1186/s13027-020-00305-8][Pereira N. M., Martins E. A.C., Quintela M. G. et al. Presence of HPV in prostate tissue from patients submitted to prostate biopsy // Acta Cir. Bras. 2023. Vol. 37, N 12. P. e371205. DOI: 10.1590/acb371205][Human papillomavirus vaccines: WHO position paper, May 2017 // Wkly. Epidemiol. Rec. 2017. Vol. 92, N 19. P. 241—268][Mo Y., Ma J., Zhang H. et al. Prophylactic and therapeutic HPV vaccines: current scenario and perspectives // Front. Cell Infect. Microbiol. 2022. Vol. 12. P. 909223. DOI: 10.3389/fcimb.2022.909223][Markowitz L. E., Schiller J. T. Human papillomavirus vaccines // J. Infect. Dis. 2021. Vol. 224, N 12 Suppl 2. P. S367—S378. DOI: 10.1093/infdis/jiaa621][Roden R. B., Ling M., Wu T. C. Vaccination to prevent and treat cervical cancer // Hum. Pathol. 2004. Vol. 35, N 8. P. 971—982. DOI: 10.1016/j.humpath.2004.04.007][Monie A., Tsen S. W., Hung C. F. et al. Therapeutic HPV DNA vaccines // Expert Rev. Vaccines. 2009. Vol. 8, N 9. P. 1221—1235. DOI: 10.1586/erv.09.76]