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IMPLEMENTATION OF A DYNAMIC SURVEILLANCE PROGRAM FOR EARLY CANCER DETECTION IN HEALTHY INDIVIDUALS CARRYING PATHOGENIC VARIANTS
- Authors: Bodunova N.A.1, Naigovzina N.B.2, Khatkov I.E.1, Mineeva D.T.1, Patrushev M.A.3, Bilyalov A.I.1,4, Danishevich A.M.1
- Affiliations:
- A. S. Loginov Moscow Clinical Scientific and Practical Center of the Moscow City Health Department, Moscow, Russian Federation, 111123
- Russian University of Medicine, Moscow, Russian Federation, 127006
- HSE University, Moscow, Russian Federation, 101000
- LIFT — Research Center for Fundamental and Applied Biomedical Studies, Moscow, Russian Federation, 121205
- Issue: Vol 34, No 4 (2026)
- Pages: 911-916
- Section: Articles
- URL: https://journal-nriph.ru/journal/article/view/2782
- DOI: https://doi.org/10.32687/0869-866X-2026-34-4-911-916
- Cite item
Abstract
The aim of the study was to develop and evaluate a multidisciplinary clinical routing model for healthy carriers of pathogenic germline variants for early cancer detection. An organizational study was conducted involving the creation of a registry of pathogenic variant carriers and implementation of a surveillance program including genetic counseling, specialist consultations, and instrumental screening. The registry included 986 carriers of pathogenic variants, including 551 clinically healthy individuals. During follow-up, 57 malignancies were detected, predominantly breast cancer; all cases were diagnosed at stages I—II. The study demonstrated that the clinical value of genetic testing is realized only within an organized system of patient routing and dynamic surveillance. The proposed model may serve as an organizational prototype for monitoring individuals at high hereditary cancer risk.
About the authors
N. A. Bodunova
A. S. Loginov Moscow Clinical Scientific and Practical Center of the Moscow City Health Department, Moscow, Russian Federation, 111123
N. B. Naigovzina
Russian University of Medicine, Moscow, Russian Federation, 127006
I. E. Khatkov
A. S. Loginov Moscow Clinical Scientific and Practical Center of the Moscow City Health Department, Moscow, Russian Federation, 111123
D. T. Mineeva
A. S. Loginov Moscow Clinical Scientific and Practical Center of the Moscow City Health Department, Moscow, Russian Federation, 111123
M. A. Patrushev
HSE University, Moscow, Russian Federation, 101000
A. I. Bilyalov
A. S. Loginov Moscow Clinical Scientific and Practical Center of the Moscow City Health Department, Moscow, Russian Federation, 111123; LIFT — Research Center for Fundamental and Applied Biomedical Studies, Moscow, Russian Federation, 121205
A. M. Danishevich
A. S. Loginov Moscow Clinical Scientific and Practical Center of the Moscow City Health Department, Moscow, Russian Federation, 111123
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