The analysis of various social, economic, and demographic factors demonstrates different degrees and directions of their impact on human body systems and human health in general. The examination of residents of several cities of Russia and neighboring countries provides an opportunity to assess strength and direction of relationship between socioeconomic factors and morphofunctional health. The comprehensive morphofunctional examination was applied to 722 young females aged 18.8±0.05 years from six cities: Moscow, Samara, Saransk, Arkhangelsk (the Russian Federation), Tiraspol (the Transdniestria Moldavian Republic), and Baku (the Republic of Azerbaijan). The economic, demographic, social and ecological indicators of the city and relevant region were considered as factors of urban environment. The Spearman's rank correlation coefficient (RS). was used as measure of relation between attributes. The variability of morphophysiological characteristics is hardly related to the population density (RS −0.18–0.15). At the same time the greatest contribution was demonstrated by complex of economic factors and environmental pollution (RS up to −0.29 for both). The relationships between functional indicators of cardiovascular system and economic status of the region, associated demographic factors, and indicators of air pollution were established in the surveyed cities. In overall, the results suggest that cardiovascular system is the most susceptible area to influence of city-level social economic factors and demonstrates deterioration of functional indicators under economic decline at the regional level. In other morphophysiological systems, adaptive changes were established only as tendencies. The deterioration conditions of human body systems under impact of urban environment factors is evident in some cities. The observed deterioration potentially can adversely affect health during growth and will further be aggravated by ongoing negative environmental influences. In this regard, it is necessary to enhance knowledge about impact of external influences on human health and body systems to develop directed preventive measures improving quality of life.

morphophysiological status, somatic health, socioeconomic factors, urban environment, cardiovascular system, respiratory system..