IS POSSIBLE TO DECREASE THE RISK OF DEVELOPMENT OF UNDESIRABLE EFFECTS OF MEDICATIONS APPLYING COMPUTER TECHNOLOGIES? (A REVIEW)

  • Authors: Shimanovskiy N.L.1,2,3,4, Shegai M.M.3,2, Roik R.O.5
  • Affiliations:
    1. The Federal State Budget Educational Institution of Higher Education N. I. Pirogov Russian National Research Medical University of Minzdrav of Russia, 117997, Moscow, Russia
    3. N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia
    4. The Federal State Budget Educational Institution of Higher Education “The G. V. Plekhanov Russian Economic University”, 115054, Moscow, Russia
    5. The Federal State Budgetary Institution "The Academician N. N. Burdenko Main Military Clinical Hospital" of Ministry of Defense of Russia, 105094, Moscow, Russia
  • Issue: Vol 31, No 4 (2023)
  • Pages: 605-612
  • Section: Articles
  • URL: https://journal-nriph.ru/journal/article/view/1842
  • DOI: https://doi.org/10.32687/0869-866X-2023-31-4-605-612
  • Cite item

Abstract


The article presents overview of modern concepts about application of artificial intelligence (AI) in pharmacotherapy to decrease risk of developing undesirable side effects of medications. The possibilities of applying AI in selection of optimal medicine or combination of medicines and prediction of treatment results are considered. The choice of the best medicine for patient usually requires integration of data of results of comprehensive examination of patient considering success of genetics and/or proteomics as well as data about chemical descriptors of compounds of medications. The prognosis of medication interactions is often based on indicators of similarity assuming that medications with analogous structures or targets will have comparable behavior or may impede each other. The optimization of scheme of dosage of medicines is implemented applying mathematical models to interpret pharmacokinetic and pharmacodynamic data.

About the authors

N. L. Shimanovskiy

The Federal State Budget Educational Institution of Higher Education N. I. Pirogov Russian National Research Medical University of Minzdrav of Russia, 117997, Moscow, Russia; ;N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia; ;The Federal State Budget Educational Institution of Higher Education “The G. V. Plekhanov Russian Economic University”, 115054, Moscow, Russia;

M. M. Shegai

N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia;

R. O. Roik

The Federal State Budgetary Institution "The Academician N. N. Burdenko Main Military Clinical Hospital" of Ministry of Defense of Russia, 105094, Moscow, Russia

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