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THE EVALUATION OF IMPACT OF FEMALE BODY MASS INDEX ON RESULTS OF TREATMENT OF INFERTILITY USING METHOD OF AUXILIARY REPRODUCTIVE TECHNOLOGIES
- Authors: Degeleva OM, Tyumina OV, Moiseeva IV
- Issue: Vol 33, No 4 (2025)
- Pages: 613-616
- Section: Articles
- URL: https://journal-nriph.ru/journal/article/view/2246
- DOI: https://doi.org/10.32687/0869-866X-2025-33-4-613-616
- Cite item
Abstract
The overweight and obesity acquire character of global epidemic, negatively affecting female fertility. The association between increased body mass index and infertility conditions higher need in application of auxiliary reproductive technologies (ART) in this category of female patients. The results of studies of affect of body mass index on efficiency of ART demonstrate certain heterogeneity. The purpose of the study is to investigate affect of overweight on results of treatment of infertility using method of auxiliary reproductive technologies. The retrospective analysis covered 1840 women treated by ART. The criteria of selection were age 30–35 years, isolated female uterine factor of infertility, single embryo transfer. The exclusion criteria were decreased ovarian reserve, multifetation, programs with donor cells. The body mass index was stratified into four categories according WHO classification. The prevalence of overweight and obesity made up to 20.2% and 16.8% correspondingly. The significant differences were found in group with obesity (BMI≥30 kg/m²): live birth rate was 1.6 times lower and miscarriage rate was 1.8 times higher as compared to group with normal weight. In case of obesity degree II (BMI 35.0–39.9 kg/m²): pregnancy rate was 1.3 times lower, live birth rate was 2.07 times lower and miscarriage rate was 2.26 times higher. The significant affection of BMI on efficiency of ART programs was established. Considering increased maternal and perinatal risks, female patients with overweight and obesity are recommended to decrease their weight before starting ART treatment.
About the authors
O M Degeleva
O V Tyumina
I V Moiseeva
References
- WHO expert consultation. Appropriate body-mass index for Asian population and its implications for policy and intervention strategies. Lancet. 2004;363:157—63. doi: 10.1016/S0140-6736(03)15268-3
- Алфёрова В И, Мустафина С В. Распространенность ожирения во взрослой популяции Российской Федерации (обзор литературы). Ожирение и метаболизм. 2022;19(1):96—105. doi: 10.14341/omet12809
- Rivera J A, Barquera S, González-Cossío T, Olaiz G, Sepúlveda J. Nutrition transition in Mexico and in other Latin American countries. Nutr. Rev. 2004;62:S149—57. doi: 10.1111/j.1753-4887.2004.tb00086.x
- Gesink Law D C, Maclehose R F, Longnecker M P. Obesity and time to pregnancy. Hum. Reprod. 2007;22:414—40. doi: 10.1093/humrep/del400
- Provost M P, Acharya K S, Acharya C R, Yeh J S, Steward R G, Eaton J L, Goldfarb J M, Muasher S J. Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008—2010 Society for Assisted Reproductive Technology registry. Fertil. Steril. 2016;105:663—9. doi: 10.1016/j.fertnstert.2015.11.008
- Rittenberg V, Seshadri S, Sunkara S K, Sobaleva S, Oteng-Ntim E, El-Toukhy T. Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis. Reprod. Biomed. Online. 2011;23:421—39. doi: 10.1016/j.rbmo.2011.06.018
- Chavarro J E, Ehrlich S, Colaci D S, Wright D L, Toth T L, Petrozza J C, Hauser R. Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction. Fertil. Steril. 2012;98:109—16. doi: 10.1016/j.fertnstert.2012.04.012
- Schuster M, Mackeen A D, Neubert A G, Kirchner H L, Paglia M J. The impact of pre-pregnancy body mass index and pregnancy weight gain on maternal and neonatal outcomes. Obstet. Gynecol. 2016;127:17s. doi: 10.1097/01.AOG.0000483316.73003.97
- Zegers-Hochschild F, Adamson G D, de Mouzon J, Ishihara O, Mansour R, Nygren K, Sullivan E, Vanderpoel S; International Committee for Monitoring Reproductive Technology;World Health Organization. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil. Steril. 2009;92:1520—4. doi: 10.1016/j.fertnstert.2009.09.009
- Rivera J A, de Cossí?o T G, Pedraza L S, Aburto T C, Sánchez T G, Martorell R. Childhood and adolescent overweight and obesity in Latin America: a systematic review. Lancet Diabetes Endocrinol. 2014;2:321—32. doi: 10.1016/S2213-8587(13)70173-6
- Barria R M, Amigo H. Nutrition transition: a review of Latin American profile. Arch. Latinoam. Nutr. 2006;56:3—11.
- Pearson N, Braithwaite R E, Biddle S J H, van Sluijs E M, Atkin A J. Associations between sedentary behavior and physical activity in children and adolescents: a metaanalysis. Obes. Rev. 2014;15:666—75. doi: 10.1111/obr.12188
- Popkin B M, Adair L S, Ng S W. Global nutrition transition and the pandemic of obesity in developing countries. Nutr. Rev. 2012;70:3—21. doi: 10.1111/j.1753-4887.2011.00456.x
- MacKenna А, Schwarze J E, Crosby J A, Zegers-Hochschild F. Outcome of assisted reproductive technology in overweight and obese women. BRA Assist. Reprod. 2017;21(2):79—83. doi: 10.5935/1518-0557.20170020
- Singh N, Gupta P, Mittal S, Malhotra N. Correlation of body mass index with outcome of in vitro fertilization in a developing country. Arch. Gynecol. Obstet. 2012;285:259—63. doi: 10.1007/s00404-011-2013-8
- Zander-Fox D L, Henshaw R, Hamilton H, Lane M. Does obesity really matter? The impact of BMI on embryo qualityand pregnancy outcomes after IVF in women age ≤38 years. Aust. N. Z. J. Obstet. Gynaecol. 2012;52:270—6. doi: 10.1111/j.1479-828X.2012.01453
- Moragianni V A, Jones S M, Ryley D A. The effect of body mass index on the outcomes of first assisted reproductive technology cycles. Fertil. Steril. 2012;98:102—8. doi: 10.1016/j.fertnstert.2012.04.004
