Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot72710.32687/0869-866X-2021-29-s2-1247-1250Научная статьяRESEARCH OF SCIENTIFIC INTEREST TO THE CHLOROQUINE USE IN CLINICAL MEDICINE IN THE BASIS OF BIBLIOMETRIC ANALYSISTolkushinA. G.tolkushin@inbox.ruLuchininE. A.-Holownia-VoloskovaM. E.-BonkaloT. I.-Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department1512202129S21247125023112021Copyright © 2021,2021Interest in chloroquine, and its analog with a more favorable safety profile - hydroxychloroquine, in 2020 is certainly associated with the outbreak of a new coronavirus infection, SARS-CoV-2. The high pathogenicity and lack of specific immunity in the population caused the rapid spread of infection with an extraordinary increase in the burden on the health systems of many countries. In such conditions, it was necessary to quickly find and implement effective methods of treatment and prevention. One of the most promising candidates for this role was hydroxychloroquine, as a multi-purpose drug with a well-studied safety profile and a rich history of use. The article describes some historical stages of the study of chloroquine and its derivatives starting from the 19th century and ending in 2020. The experience of its use for the treatment of diseases such as malaria, rheumatoid arthritis, diabetes, bronchial asthma, photosensitivity and skin porphyria was reviewed. Separately, some historical aspects of its use for the treatment of viral and oncological diseases were considered. The bibliometric method used in this scientific work clearly demonstrates the dynamics of the changing interest of the scientific community in chloroquine and its derivatives. Chloroquine and its derivatives can definitely be attributed to «pharmaceutical centenarians» with an intense life that continues.COVID-19chloroquinehistorymalariaCOVID-19cancerdrug developmentrepurposingхлорохинаминохинолиновые препаратыисториямаляриянаукометрический анализрепозиционирование лекарственных препаратов1.Alley G. History of a case of diabetes mellitus, successfully treated by animal diet, and the use of the cinchona, with remarks // Edinb. Med. Surg. J. 1808. Vol. 4, N 13. P. 35-41.2.Kinglake. On the effects of cinchona bark, in acute gout and rheumatism // Med. Phys. J. 1808. Vol. 19, N 111. P. 427-429.3.Payne J. F. A postgraduate lecture on lupus erythematosus // Clin. J. 1894. Vol. 4. P. 223-239.4.Лисицына Т. А., Кошелева Н. М. Антималярийные препараты в терапии системной красной волчанки: прошлое, настоящее, будущее // Современная ревматология. 2010. T. 4, № 2. С. 81-88. DOI: 10.14412/1996-7012-2010-608.5.Martenstein H. Subacute lupus erythematosus and tubercular cervical adenopathy. Treatment with plasmochin (in German) // Z. Haut Geschlechtskr. 1928. Vol. 27. P. 2488249.6.Remarks on the exhibition of sulphate of quinine in acute rheumatism // Med. Chir. Rev. 1830. Vol. 13, N 26. P. 437-438.7.Прокопчук А. Я. Лечение красной волчанки акрихином. Минск, 1939. 12 с.8.Shee J. C. Lupus erythematosus treated with chloroquine // Lancet. 1953. Vol. 265, N 6778. P. 201-202. DOI: 10.1016/s0140-6736(53)90138-x.9.Haydu G. G. Rheumatoid arthritis therapy; a rationale and the use of chloroquine diphosphate // Am. J. Med. Sci. 1953. Vol. 225, N 1. P. 71-75.10.Page F. Treatment of lupus erythematosus with mepacrine // Lancet. 1951. Vol. 2, N 6687. P. 755-758. DOI: 10.1016/s0140-6736(51)91643-1.11.Freedman A., Bach F. Mepacrine and rheumatoid arthritis // Lancet. 1952. Vol. 2, N 6729. P. 321. DOI: 10.1016/s0140-6736(52)92481-1.12.Zipper J., Cole L. P., Goldsmith A. et al. Quinacrine hydrochloride pellets: preliminary data on a nonsurgical method of female sterilisation // Int. J. Gynaecol. Obstet. 1980. Vol. 18, N 4. P. 275-290. DOI: 10.1002/j.1879-3479.1980.tb00496.x.