Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot46710.32687/0869-866X-2021-29-1-14-24Научная статьяThe weekly cycle of mortality among patients with COVID-19TepponeM.mikhail.teppone@gmail.comNano City Holdings Berhad15122021291142406042021Copyright © 2021,2021The statistical data on mortality due to COVID-19 has been studied. The weekly cycle of mortality was established. Presumably, the decreased mortality on particular days of the week related to optimized treatment protocols applied on the «favorable days». If the factors reducing mortality on particular days of the week could be identified, their positive effect should be applied to other days of the week to decrease mortality among patients with COVID-19.COVID-19COVID-19пандемиянедельный цикл смертности1.Liu Y. C., Kuo R. L., Shih S. R. COVID-19: The first documented coronavirus pandemic in history. Biomed J. 2020 Aug;43(4):328-33. doi: 10.1016/j.bj.2020.04.007. Epub 2020 May 5.2.Li Q., Guan X. H., Wu P. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus - Infected Pneumonia. N. Engl. J. Med. 2020;382(13):1199-07.3.Lucey D., Kent K. Coronavirus - Unknown Source, Unrecognized Spread, and Pandemic Potential. - Think Global Health, Feb 6, 2020. Режим доступа: https://www.thinkglobalhealth.org/article/coronavirus-unknown-source-unrecognized-spread-and-pandemic-potential (дата обращения 20.09.2020).4.Nesteruk I. Waves of COVID-19 pandemic. Detection and SIR simulations. medRxiv. 2020. doi: 10.1101/2020.08.03.20167098. Epub. August 04, 2020.5.Worldometers: Coronavirus Worldwide Graphs. Режим доступа: https://www.worldometers.info/coronavirus/worldwide-graphs/ (дата обращения 20.09.2020).6.Imai N., Dorigatti I., Cori A., et al. Report 1 - Estimating the potential total number of novel Coronavirus cases in Wuhan City, China - January 17, 2020. Режим доступа: https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/COVID-19/report-1-case-estimates-of-COVID-19/ (дата обращения 20.09.2020).7.Imai N., Dorigatti I., Cori A. Report 2 - Estimating the potential total number of novel Coronavirus (2019-nCoV) cases in Wuhan City, China - January 22, 2020. Режим доступа: https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/COVID-19/report-2-update-case-estimates-COVID-19/ (дата обращения 20.09.2020).8.Wuhan Coronavirus. - Speakers: Jeremy Farrar, Juliana Chan, Stéphane Bancel, Richard Hatchett. - Davos: WEForum, Jan 23, 2020 15:15 - 15:45 CET. Режим доступа: https://www.weforum.org/events/world-economic-forum-annual-meeting-2020/sessions/update-wuhan-coronaviru (дата обращения 20.09.2020).9.Врач: Иммуномодуляторы опасны при коронавирусе. Росбалт, 30 января 2020. Режим доступа: https://www.rosbalt.ru/piter/2020/01/30/1825299.html (дата обращения 20.09.2020).10.Вступительное слово Генерального директора на пресс-брифинге по COVID-19, 11 марта 2020 г. - WHO, 11 Mar 2020. Режим доступа: https://www.who.int/ru/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-COVID-19--11-march-2020 (дата обращения 20.09.2020).11.Вступительное слово Генерального директора на пресс брифинге по COVID-19. - WHO, 16 марта 2020 г. Режим доступа: https://www.who.int/ru/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-COVID-19--16-march-2020 (дата обращения 20.09.2020).12.Ferguson N. M., Laydon D., Nedjati-Gilani G. Report 9 - Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. Imperial College London, March 16, 2020. Режим доступа: https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/COVID-19/report-9-impact-of-npis-on-COVID-19/ (дата обращения 20.09.2020).13.Status of COVID-19: As of 19 March 2020, COVID-19 is no longer considered to be a high consequence infectious disease (HCID) in the UK. Режим доступа: https://www.gov.uk/guidance/high-consequence-infectious-diseases-hcid?fbclid=IwAR0ePjBbK8iCinhFq7zfuBLrRFS0i1VIepiVhgSyF4qjTuqj-c251jybDiI#status-of-COVID-19 (дата обращения 20.09.2020).14.Salje H., Kiem C. T., Lefrancq N. Estimating the burden of SARS-CoV-2 in France. Science. 2020;369(6500):208-11. doi: 10.1126/science.abc351715.Fenton N., Osman M., Neil M., McLachlan S. Study suggests more people have had coronavirus than previously estimated. - Medicalxpress, June 26, 2020. Режим доступа: https://medicalxpress.com/news/2020-06-people-coronavirus-previously.html (дата обращения 20.09.2020).16.The CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel. - Atlanta, GA: Centers for Disease Control and Prevention, 2020, July 13:37-8.17.COVID19 PCR Tests are Scientifically Meaningless. - BPA, 01.07.2020. Режим доступа: https://bpa-pathology.com/covid19-pcr-tests-are-scientifically-meaningless/ (дата обращения 20.09.2020).18.Книга Пророка Исаии. гл. 65: стих 20. В кн.: Толковая Библия, или Комментарии на все книги Священного Писания Ветхого и Нового Завета. Петербургъ: Приложение к журналу «Странник». 1908;5:540.19.Teppone M. Medicine has always been “Modern” and “Scientific” from ancient times to the present day. J. Integrat. Med. 2019;17(4):229-37.20.Лихорадка: Патогенез. В кн.: Адо А. Д., Адо М. А., Пыцкой В. И., ред. Патологическая физиология. М.: Триада-Х; 2000. С. 203-6.21.Wong T., Stang A. S., Ganshorn H., et al. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Evid Based Child Health. 2014;9(3):675-729.22.Zhang Z. J. Shang Han Lun: Treatise on Febrile Diseases Caused by Cold. Beijing: New World Press; 1986.23.Selye H. A syndrome produced by diverse nocuous agents. Nature. 1936;138(3479):32.24.Isatidis Folium and Radix (Da Qing Ye / Ban Lan Gen). In: Bensky D., Clavey S. C., Stoger E. Materia Medica (3rd ed). Seattle: Eastland Press; 2004. P. 156-60.25.Для защиты от вирусов ученые ТГУ предлагают использовать растение. Seldon News, 24 марта 2020. Режим доступа: https://news.myseldon.com/ru/news/index/226298305 (дата обращения 20.09.2020).26.Граф Н. Томские ученые нашли растение, защищающее от коронавируса. Российская газета. 25 марта 2020. Режим доступа: https://rg.ru/2020/03/25/reg-sibfo/tomskie-uchenye-rekomendovali-dlia-zashchity-ot-virusa-vajdu-krasilnuiu.html (дата обращения 20.09.2020).27.Boosting Your Immune System in Times of Viral Respiratory Outbreaks. Thailand Medical News. Feb 2, 2020. Режим доступа: https://www.thailandmedical.news/news/boosting-your-immune-system-in-times-of-viral-respiratory-outbreaks (дата обращения 20.09.2020).28.Mueller A. L., McNamara M. S., Sinclair D. A. Why does COVID-19 disproportionately affect older people? - Aging (Albany,NY). 2020;12:9959-9981. doi: 10.18632/aging.10334429.Palmer S., Cunniffe N., Donnelly R. Risk of COVID-19 hospitalisation rises exponentially with age, inversely proportional to T-cell production. medRxiv. 2020, Aug 31. doi: 10.1101/2020.08.25.2018148730.Diao B., Wang C. H., Tan Y. J. Reduction and Functional Exhaustion of T-Cells in Patients with Coronavirus Disease 2019 (COVID-19). medRxiv preprint. 2020, Feb 20. doi: 10.1101/2020.02.18.2002436431.To K. K.-W., Tsang O. T.-Y., Leung W.-S. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2- Lancet Infect. Dis. 2020 May 1;20(5):565-74.32.Khamsi R. Why those most at risk of COVID-19 are least likely to respond to a vaccine. - National Geographic, 20 July 2020. Режим доступа: сайте: https://www.nationalgeographic.co.uk/science-and-technology/2020/07/why-those-most-at-risk-of-COVID-19-are-least-likely-to-respond-to-a (дата обращения 20.09.2020).33.Wooldridge L. C. Versucheüber Schutzimpfungaufchemischem Wege (Jun, 1888). Arch Anat Phys Wissen Med (Leipzig). 1888;2:527-36.34.Liu Y. P., Pan Y., Hu Z. H. Thymosin Alpha 1 Reduces the Mortality of Severe Coronavirus 2019 by Restoration of Lymphocytopenia and Reversion of Exhausted T Cells. Clin. Infect. Dis. 2020 May 22;ciaa630. doi: 10.1093/cid/ciaa63035.Машковский М. Лекарственные средства. Изд. 16-е. М.: Новая Волна; 2012. C. 726-8.36.Лукьянов С. А., Кузник Б. И., Хавинсон В. Х. Использование Тималина для коррекции отклонений иммунного статуса при COVID-19 (обоснование применения препарата и описание клинического случая). Врач. 2020;(8):74-82. doi: 10.29296/25877305-2020-08-1237.Worldometers: Reported Cases and Deaths by Country, Territory, or Conveyance. Режим доступа: https://www.worldometers.info/coronavirus/#countries (дата обращения 20.09.2020).38.Ricon-Becker I., Tarrasch R., Blinder P., Ben-Eliyahu S. A seven-day cycle in COVID-19 infection and mortality rates: Are inter-generational social interactions on the weekends killing susceptible people? medRxiv. May 08, 2020 doi: 10.1101/2020.05.03.2008950839.Worldometers: Reported Cases and Deaths by Country, Territory, or Conveyance: United States. Режим доступа: https://www.worldometers.info/coronavirus/country/us/ (дата обращения 11.12.2020).40.Goguet A.-Y. De L'Origine des Loix, des Arts, et des Sciences: et de leurs progres chez les anciens peuples. Vol. 1. La Haye: Pierre Gosse Junior; 1758. P. 474-5.41.Needham J., Ling W. Science and Civilization in China. Vol. 3: Mathematics and the Sciences of the Heavens and the Earth. Cambridge: Cambridge University Press; 1959. P. 390-408.42.Zerubavel E. Hidden Rhythms: Schedules and Calendars in Social Life. Berkeley: University of California Press; 1985.43.Aylin P. Making sense of the evidence for the «weekend effect». BMJ. 2015 Sep 5;351:h4652. doi: 10.1136/bmj.h465244.Гундаров И. Когда лечение страшнее болезни. 2020. Режим доступа: https://www.youtube.com/watch?v=UnYbpK_3V90&t=19s (дата обращения 11.12.2020)