Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot42010.32687/0869-866X-2020-28-s2-1118-1122Научная статьяHistory of aminoquinoline preparations: from cinchona bark to chloroquine and hydroxychloroquinonTolkushinA. G.-LuchininE. A.-Kholovnya-VoloskovaM. E.kholovnyame@zdrav.mos.ruZavyalovA. A.-State Budgetary Institution “Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department”15122020281118112206042021Copyright © 2020,2020The article presents a review of the historical facts related to the discovery and introduction of chloroquine and hydroxychloroquine. The history of studying aminoquinoline preparations is associated with the discovery of the antimalarial action of the bark of the quinine tree, the isolation of quinine from other active substances - alkaloids and the determination of their structure. The structural similarity of quinine and one of the first chemically synthesized dyes - methylene blue-was an important factor at the beginning of the synthesis of molecules with antimalarial activity in the 1930s in Germany. Pamaquin (plasmoquin, plasmoсid), quinacrine (quinacrine, Atebrin, Mepacrine), sontoquine (sontochin), chloroquine, primaquine, hydroxychloroquine, and mefloquine (Lariam) were consistently introduced in medical practice. Many of these medications are no longer widely used. However, chloroquine and hydroxychloroquine have not lost their relevance. The scope of their use has been expanded.chloroquinehydroxychloroquinehistory of antimalarial aminoquinoline medicinesхлорохингидроксихлорохинистория противомалярийных аминохинолиновых лекарственных препаратов1.Flückiger F. A., Hanbury D. Pharmacographia: a history of the principle drugs of vegetable origin, met with in Great Britain and British India. London: MacMillan and Co.; 1874:302-31.2.Guerra F. 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