Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot269810.32687/0869-866X-2026-34-3-657-661Научная статьяTHE CHARACTERISTICS OF COURSE OF PREGNANCY RESULTED FROM EXTRA-CORPOREAL IMPREGNATION AGAINST THE BACKGROUND OF GESTATIONAL DIABETES MELLITUS DEPENDING ON TERMS OF MANIFESTATIONBatrakN. V.IvanovaI. V.The Federal State Budgetary Educational Institution of Higher Education “The Ivanovo State Medical University” of the Minzdrav of Russia, 153012, Ivanovo, Russia0707202634365766107072026Copyright © 2026,2026The pregnancy that occurred due to in vitro fertilization is characterized by higher risk of development of gestational diabetes mellitus. The purpose of the study was to investigate course and outcomes of pregnancy resulted from in vitro fertilization in women with gestational diabetes mellitus, depending on time of its manifestation. The analysis of course of pregnancy, childbirth and condition of newborns in 179 women with gestational diabetes mellitus under pregnancy resulted from in vitro fertilization was carried out. It is established that early manifestation of gestational diabetes mellitus is associated with older age of pregnant women, higher rate of birth of large fetus in anamnesis, higher body mass index, more frequent prescription of insulin therapy to treat gestational diabetes mellitus, higher rate of development of early threatened miscarriage, isthmic cervical insufficiency, anemia, chronic arterial hypertension, gestational arterial hypertension, moderate preeclampsia, severe preeclampsia, premature normally placed placenta detachment, fetal growth retardation, chronic intrauterine fetal hypoxia, diabetic fetopathy, prenatal rupture of amniotic fluid, premature birth, more frequent birth of large fetus, development of fetal renal pyelectasia. The female patients with late manifestation of gestational diabetes mellitus had higher level of fasting plasma glycemia, frequent development of placenta previa, polyhydramnios, pathological and insufficient gain of body mass during pregnancy, dis-coordination of labor and clinically narrow pelvis during labor, more frequent operative delivery and early delivery. The gestational diabetes mellitus, developed both in early and late periods, complicates the course and childbirth under pregnancy resulted from in vitro fertilization, adversely affects state of the newborn. The study in depth is needed to establish possible mechanisms of development of gestational diabetes mellitus in this cohort of women with implementation of screening examinations and determination of further tactics of management of pregnancy depending on time of its manifestation.gestational diabetes mellituscourse of pregnancyperinatal outcomesin vitro fertilizationгестационный сахарный диабеттечение беременностиперинатальные исходыэкстракорпоральное оплодотворение[Ashrafi M., Gosili R., Hosseini R., Arabipoor A., Ahmadi J., Chehrazi M. Risk of gestational diabetes mellitus in patients undergoing assisted reproductive techniques. Eur. J. Obstet. Gynecol. Reprod. Biol. 2014;176:149—52. doi: 10.1016/j.ejogrb.2014.02.009][Guariguata L., Linnenkamp U., Beagley J., Whiting D. R., Cho N. H. Global estimates of the prevalence of hyperglycaemia in pregnancy. Diabetes Res. Clin. Pract. 2014;103(2):176—85. doi: 10.1016/j.diabres.2013.11.003][Jiang F., Li Y., Sun L. Association between gestational weight gain and adverse neonatal outcomes in women conceiving with assisted reproductive technology: Evidence from the NVSS 2019—2021. PLoS One. 2023;18(10):e0292665. doi:10.1371/journal.pone.0292665][Kouhkan A., Hosseini R., Baradaran H. R., Arabipoor A., Cheraghi R., Moini A., et al. Early Postpartum Glucose Intolerance, Metabolic Syndrome and Gestational Diabetes Mellitus Determinants after Assisted Conception: A Prospective Cohort Study. Int. J. Fertil. Steril. 2022;16(3):172—9. doi: 10.22074/ijfs.2021.522566.1070][Фетисова И. Н., Батрак Н. В. Генетические аспекты гестационного сахарного диабета. Quid est veritas? 2025;30(3):50—9. doi: 10.52246/1606-8157_2025_30_3_50][Albonici L., Benvenuto M., Focaccetti C., Cifaldi L., Miele M. T., Limana F., et al. PlGF Immunological Impact during Pregnancy. Int. J. Mol. Sci. 2020;21(22):8714. doi: 10.3390/ijms21228714][Fabozzi G., Verdone G., Allori M., Cimadomo D., Tatone C., Stuppia L., et al. Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation. Nutrients. 2022;14(9):1918. doi: 10.3390/nu14091918][Lorenzo-Almorós A., Hang T., Peiró C., Soriano-Guillén L., Egido J., Tuñón J., et al. Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases. Cardiovasc. Diabetol. 2019;18(1):140. doi: 10.1186/s12933-019-0935-9][Hill M. J., Uyehara C. F., Hashiro G. M., Frattarelli J. L. The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle. J. Assist. Reprod. Genet. 2007;24(5):183—8. doi: 10.1007/s10815-007-9106-0][Мелкозерова О. А., Мурзин А. В., Третьякова Т. Б., Дерябина Е. Г. Молекулярно-генетические предикторы перинатальных осложнений гестационного сахарного диабета у беременных после применения вспомогательных репродуктивных технологий. Российский журнал здоровья женщины и ребенка. 2024;7(1):4—11. doi: 10.32364/2618-8430-2024-7-1-1]