Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot253110.32687/0869-866X-2026-34-1-108-112Научная статьяTHE PRECISION APPROACH IN CONTEMPORARY NEUROSURGICAL PRACTICE: A REVIEWAnnikovYu. G.ChekhonatskiyA. A.KomlevaN. E.FilatovD. N.TsyganovV. I.ChekhonatskiyV. A.AnnikovaO. V.The Federal State Budget Educational Institution of Higher Education "The V. I. Razumovsky Saratov State Medical University of Minzdrav of Russia", 410012, Saratov, RussiaThe Federal State Budget Educational Institution of Additional Professional Education "The Russian Medical Academy of Continuous Professional Education" of Minzdrav of Russia, 125445, Moscow, Russia-=3=-2102202634110811221022026Copyright © 2026,2026The review was based on analysis of 180 sources from databases PubMed, eLibrary, Cohrane Library, MEDLINE for 2015–2025 using keywords precision medicine, personalized medicine, neuro-oncology, oncology, cranio-cerebral injury, neuro-trauma, neuro-proteomics and AI. The purpose of the study was to demonstrate, on the basis of analysis of publications on precision medicine application in neurosurgery, the significance and perspectives of mentioned approach in modern neurosurgical practice. The methods of precision medicine, digital revolution and progress in multi-modal Big Data processing permit to better understand of tumor genesis, their clinical heterogeneity, functional effects and causes underlying their resistance to treatment. The precision medicine methods provide valuable information on pathophysiological mechanisms underlying neuro-trauma through analysis of complex protein interactions and changes. The future of precision medicine in neurosurgical practice is in permanent enhancement of AI and machine learning, permitting rapid and accurate decision-making based on comprehensive molecular data. 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