Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot245210.32687/0869-866X-2025-33-6-1336-1343Научная статьяThe methodology of integral evaluation of readiness of regional health care system to respond to global challengesOrlovS. A.AleksandrovaO. Yu.N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia151220253361336134319122025Copyright © 2025,2025The article presents scientific methodology of comprehensive (integral) assessment of regional health care system readiness to respond to biological (pandemics, epidemics), technological (accidents, disasters) and military (armed conflicts, terrorist attacks) global challenges. The analysis was carried out concerning existing methodologies and algorithms of assessing readiness of health care systems and medical organizations in the Russian Federation and abroad. The International Health Regulations and associated WHO tools, global health security indices, national indices and readiness checklists were covered by analysis. Their efficiency were evaluated on the basis of expert data and COVID-19 pandemic experience. The mathematical model of integral evaluation of readiness were developed that included set of key indicators (infrastructural, resource-based, managerial, epidemiological, etc.) and criteria system. The methodology of calculation of integral index, considering weighting coefficients of indicators and aggregated sub-indices, is proposed. The examples of application of methodology at regional level are provided. 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