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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Problems of Social Hygiene, Public Health and History of Medicine</journal-id><journal-title-group><journal-title>Problems of Social Hygiene, Public Health and History of Medicine</journal-title></journal-title-group><issn publication-format="print">0869-866X</issn><issn publication-format="electronic">2412-2106</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">2395</article-id><article-id pub-id-type="doi">10.32687/0869-866X-2025-33-5-1236-1242</article-id><article-categories><subj-group subj-group-type="heading"><subject>Научная статья</subject></subj-group></article-categories><title-group><article-title>THE SELF-ORGANIZATION AND SYNERGISTIC EFFECTS IN THE SYSTEM OF ANTI-NARCOTIC STATE STRATEGY OF THE REGION</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Akhokhova</surname><given-names>A. V.</given-names></name><email></email><xref ref-type="aff" rid="aff-1"/><xref ref-type="aff" rid="aff-2"/><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Tlakadugova</surname><given-names>M. Kh.</given-names></name><email></email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Akhmetov</surname><given-names>A. V.</given-names></name><email></email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Vologirov</surname><given-names>A. S.</given-names></name><email></email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Piakartova</surname><given-names>Z. M.</given-names></name><email></email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Gadzaeva</surname><given-names>T. Kh.</given-names></name><email></email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Bozieva</surname><given-names>M. A.</given-names></name><email></email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Masaeva</surname><given-names>M. M.</given-names></name><email></email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Atmurzaeva</surname><given-names>D. R.</given-names></name><email></email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kalin</surname><given-names>I. Ya.</given-names></name><email></email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff id="aff-1">The Society with Limited Liability “The Firm “SEM””, 360017, Nalchik, Russia</aff><aff id="aff-2">The Federal State Budget Educational Institution of Higher Education “The H. M. Berbekov Kabardino-Balkaria State University” of the Minobrnauka of Russia, 360004, Nalchik, Russia</aff><aff id="aff-3">The State Budget Institution “The Republican Clinical Center of Psychiatry and Narcology” of the Minzdrav of the Kabardino-Balkaria Republic, 360032, Nalchik, Russia</aff><aff id="aff-4">The Federal State Budget Educational Institution of Higher Education “The Russian State Social University”, 129226, Moscow, Russia</aff><pub-date date-type="epub" iso-8601-date="2025-11-08" publication-format="electronic"><day>08</day><month>11</month><year>2025</year></pub-date><volume>33</volume><issue>5</issue><fpage>1236</fpage><lpage>1242</lpage><history><pub-date date-type="received" iso-8601-date="2025-11-12"><day>12</day><month>11</month><year>2025</year></pub-date></history><permissions><copyright-statement>Copyright © 2025,</copyright-statement><copyright-year>2025</copyright-year></permissions><abstract>The anti-narcotic activity is targeted to formation of unified system of comprehensive anti-narcotic preventive policy oriented on harmonization and coordination of processes between subjects of interdepartmental interaction of the Strategy. The purpose of the study was to establish optimal approach and principles in formation of synergistic effects between people, departments, civil society institutions, including public and non-profit organizations that make up social structure — state anti-narcotic Strategy in the region. The conclusion is made that characteristics of implementation of the Strategy for each subject of prevention at meso-level (region) set necessary potential for development and manifestation of synergistic effects leveling out existing patterns, with established vertical line of hierarchy of relations in health care sector. According to researchers, linearity, closure, lack of conditions for changes and transformations, “unjustified stability” impede self-organization and therefore to receive synergistic effects from interdepartmental interaction.</abstract><kwd-group xml:lang="en"><kwd>anti-narcotic activity</kwd><kwd>Strategy</kwd><kwd>meso-level</kwd><kwd>self-organization</kwd><kwd>synergistic effects</kwd><kwd>regularities of system: interdepartmental interaction</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>антинаркотическая деятельность</kwd><kwd>Стратегия</kwd><kwd>мезоуровень</kwd><kwd>самоорганизация</kwd><kwd>синергетические эффекты</kwd><kwd>закономерности системы</kwd><kwd>межведомственное взаимодействие</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Хакен Г. Синергетика. М.: Мир; 1980. 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