Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot22710.32687/0869-866X-2019-27-6-1086-1092Научная статьяThe system of epidemiological control of hepatitis E and complex of anti-epidemic, hygienic and veterinary sanitary activities in the Belgorod oblastPolyakovA. D.postoscol@mail.ruKhmyrovA. V.-KyuregianK. K.-MalinnikovaE. Yu.-MikhailovM. I.-The Skolkovo Territorial Department of the Board of Rospotrebnadzor in City of MoscowThe Federal State Autonomous Educational Institution of Higher Education “The Belgorod State National Research Institute”The Federal State Budget Scientific Institution “The I. I. Mechnikov Research Institute of Vaccines and Sera”151220192761086109206042021Copyright © 2019,2019The Hepatitis E (HE) is a viral liver disease that is common on all continents at different rates and very frequently is not symptomatically distinguishable from other viral hepatitis, such as hepatitis A, B and C, as well as from other infectious diseases referred to as “acute jaundice syndrome”. The GE-anthroponosis (in the case of infection caused by genotypes 1 or 2 of hepatitis E virus) or anthropozoonosis (in the case of infection caused by 3 or 4 viruses) is predominantly propagated through fecal-oral transmission. The article presents the general characteristics of VGE, human risk factors and means of prevention. The particular attention is paid to the development of complex of anti-epidemic, hygienic and veterinary sanitary measures in the Belgorod Oblast.viral hepatitis Eanthropozoonosisautochthonousmorbiditycirculationvirus eliminationrisk factorsmethods of preventionвирусный гепатит Еантропозоонозавтохтонныйзаболеваемостьциркуляцияраспространение у свинейэлиминация вирусафакторы рискаспособы профилактики1.Кюрегян К. К. Заболеваемость острым гепатитом Е в РФ. Современные проблемы науки и образования. 2014;(2):18-22.2.Михайлов М. И. Энтеральные вирусные гепатиты (этиология, эпидемиология, диагностика, профилактика). М.: ВУНМЦ Росздрава; 2007.3.Поляков А. Д. Особенности эпидемического процесса гепатита Е в Белгородской области. Научные ведомости Белгородского государственного университета. 2016;5(226):79-83.4.Pavio N., Doceul V., Bagdassarian E., Johne R. Recent knowledge on hepatitis E virus in Suidae reservoirs and transmission routes to human. Vet. Res. 2017;48:78.5.Colson P., Borentain P., Queyriaux B., Kaba M., Moal V., Gallian P., Heyries L., Raoult D., Gerolami R. Pig liver sausage as a source of hepatitis E virus transmission to humans. J. Infect. Dis. 2010;202:825-34.6.Guillois Y., Abravanel F., Miura T., Pavio N., Vaillant V., Lhomme S., Le Guyader F. S., Rose N., Le Saux J. C., King L. A. High Proportion of Asymptomatic Infections in an Outbreak of Hepatitis E Associated with a Spit-Roasted Piglet, France, 2013. Clin. Infect. Dis. 2016;62:351-7.7.Riveiro-Barciela M., Mínguez B., Gironés R., Rodriguez-Frías F., Quer J., Buti M. Phylogenetic demonstration of hepatitis E infection transmitted by pork meat ingestion. Gastroenterology. 2015;49: 165-8.8.Morozov V. A., Morozov A. V., Rotem A., Barkai U., Bornstein S., Denner J. Extended microbiological characterization of Göttingen minipigs in the context of xenotransplantation: detection and vertical transmission of hepatitis E virus. PLoS ONE. 2015;10:4-8.9.Zhu F. C., Zhang J., Zhang X. F., Zhou C., Wang Z. Z., Huang S. J., Wang H., Yang C. L., Jiang H. M., Cai J. P. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: A large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet. 2010;376;895-902.10.Wu T., Li S. W., Zhang J., Ng M. H., Xia N. S., Zhao Q. Hepatitis E vaccine development: A 14-year odyssey. Hum. Vaccin. Immunother. 2012;8:823-7.11.Sanford B. J., Opriessnig T., Kenney S. P., Dryman B. A., Córdoba L., Meng X. J. Assessment of the cross-protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses (HEV) against challenge with a genotype 3 HEV in pigs. Vaccine. 2012;30:6249-55.12.Salines M., Barnaud E., Andraud M., Eono F., Renson P., Bourry O., Pavio N., Rose N. Hepatitis E virus chronic infection of swine co-infected with Porcine Reproductive and Respiratory Syndrome Virus. Vet. Res. 2015;46:55.13.Евдокимов В. И., Поляков А. Д., Ковалева Г. И., Феттер В. В. Гигиенические проблемы утилизации органических отходов и пути их решения в Белгородской области. В кн.: Материалы XI Всероссийского съезда гигиенистов и санитарных врачей. М.: 2012. T. 1. C. 436-9.14.Брико Н. И., Онищенко Г. Г., Покровский В. И. Руководство по эпидемиологии инфекционных болезней. М.: Медицинское информационное агентство; 2019. С. 795-800.