Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot178810.32687/0869-866X-2024-32-s2-1143-1146Научная статьяSTUDY OF PREVENTION STRATEGIES FOR SIX RISK FACTORS IN REDUCING MORTALITY FROM NON-COMMUNICABLE DISEASES 25 × 25OynotkinovaO. Sh.MatskeplishviliS. T.MaslennikovaO. M.LysenkoM. A.Research Institute of Health Care Organization and Medical Management of the Moscow Health Care Department, 115088, Moscow, RussiaCentral State Medical Academy of the Office of the President of the Russian Federation, 121359, Moscow, RussiaMedical Scientific and Educational Center of Lomonosov Moscow State University, 119234, Moscow, RussiaCity Clinical Hospital Nо. 52 of the Moscow Health Department, 123182, Moscow, Russia08112024321143114602072025Copyright © 1970,1970Non-communicable diseases (NCDs) continue to progress against the background of an increase in risk factors and the emergence of new ones, such as postcovid syndrome. Due in part to this influence, the progression of the atherosclerotic process and deterministic cardiovascular diseases is observed. In this regard, the aggravation of NCDs remains alarming against the background of the influence of six leading risk factors «25 × 25». The article presents a review of the literature and the conceptual directions of these leading factors as dominant in the development of NCDs. The directions of secondary prevention are considered and the expediency of their early implementation is justified. The presented methodological bibliometric method made it possible to analyze the experience of a number of countries that led to a decrease in the development of NCDs. The methods of bibliographic data search included search queries on the Scopus Web of Sciense, MedLine, The Cochrane Lybrary, PubMed databases. It is noted that achieving even six goals with the correction of risk factors will reduce morbidity and mortality from such four major NCDs as cardiovascular diseases, chronic obstructive pulmonary disease, stomach cancer, diabetes mellitus by 2025 to levels close to the target of «25 × 25», reducing by 77% the gap between the growth situation or stagnation and trends in the growth of new risk factors.«25 × 25»six risk factorstobacco smokingalcoholblood pressurecardiovascular diseaseschronic obstructive pulmonary diseasestomach cancerdiabetes mellitussaltpreventionnon-communicable diseasesmortality«25 × 25»факторы рискатабакокурениеалкогольартериальное давлениесердечно-сосудистые заболеванияхроническая обструктивная болезнь лёгкихрак желудкасахарный диабетсольпрофилактиканеинфекционные заболеваниясмертность1.Драпкина О. М., Концевая А. В., Калинина А. М., и др. Профилактика хронических неинфекционных заболеваний в Российской Федерации. Национальное руководство 2022 // Кардиоваскулярная терапия и профилактика. 2022. Т. 21, №4. С. 3235. DOI: 10.15829/1728-8800-2022-32352.Калинина А. М., Соколов Г. Е., Горный Б. Э. Медицинская профилактика хронических неинфекционных заболеваний в первичном звене здравоохранения // Профилактическая медицина. 2020. Т. 23, №2. С. 53—58. DOI: 10.17116/profmed202023021533.Lozano R., Naghavi M., Foreman K. et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010 // Lancet. 2012. Vol. 380, N 9859. P. 2095—128. DOI: 10.1016/S0140-6736(12)61728-04.Di Cesare M., Khang Y. H., Asaria P. et al. Inequalities in noncommunicable diseases and effective responses // Lancet. 2013. Vol. 381, N 9866. P. 585—597. DOI: 10.1016/S0140-6736(12)61851-05.Brotons C., Björkelund C., Bulc M. et al. Prevention and health promotion in clinical practice: the views of general practitioners in Europe // Prev. Med. 2005. Vol. 40, N 5. P. 595—601. DOI: 10.1016/j.ypmed.2004.07.0206.Bloom D. E., Cafiero E. T., Jané-Llopis E. et al. The global economic burden of non-communicable diseases. Geneva; 2011. 48 р.7.Bonita R., Magnusson R., Bovet P., et al. Country actions to meet UN commitments on non-communicable diseases: a stepwise approach // Lancet. 2013. Vol. 381, N 9866. P. 575—584. DOI: 10.1016/S0140-6736(12)61993-X8.Ezzati M., Riboli E. Behavioral and dietary risk factors for noncommunicable diseases // N. Engl. J. Med. 2013. Vol. 369, N 10. P. 954—964. DOI: 10.1056/NEJMra12035289.Ezzati M., Riboli E. Can noncommunicable diseases be prevented? Lessons from studies of populations and individuals // Science. 2012. Vol. 337, N 6101. P. 1482—1487. DOI: 10.1126/science.122700110.Jha P., Peto R. Global effects of smoking, of quitting, and of taxing tobacco // N. Engl. J. Med. 2014. Vol. 370, N 1. P. 60—68. DOI: 10.1056/NEJMra130838311.Di Cesare M., Bennett J. E., Best N. et al. The contributions of risk factor trends to cardiometabolic mortality decline in 26 industrialized countries // Int. J. Epidemiol. 2013. Vol. 42, N 3. P. 838—848. DOI: 10.1093/ije/dyt063