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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Problems of Social Hygiene, Public Health and History of Medicine</journal-id><journal-title-group><journal-title>Problems of Social Hygiene, Public Health and History of Medicine</journal-title></journal-title-group><issn publication-format="print">0869-866X</issn><issn publication-format="electronic">2412-2106</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">175</article-id><article-id pub-id-type="doi">10.32687/0869-866X-2019-27-5-796-802</article-id><article-categories><subj-group subj-group-type="heading"><subject>Научная статья</subject></subj-group></article-categories><title-group><article-title>The organizational aspects of early diagnostic of metabolic syndrome on the basis of implementation of new genetic, cellular and bio-informational technologies</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Khabriev</surname><given-names>R. U.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kakorina</surname><given-names>E. P.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kuzmina</surname><given-names>L. P.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Fishman</surname><given-names>B. B.</given-names></name><bio></bio><email>Fishman@mxc.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Prozorova</surname><given-names>I. V.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Raff</surname><given-names>S. A.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Abdulin</surname><given-names>A. A.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Iukhno</surname><given-names>M. V.</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff id="aff-1">N. A. Semashko National Research Institute of Public Health</aff><aff id="aff-2">The Federal State Autonomous Educational Institution of Higher Education “The I. M. Sechenov First Moscow State Medical University” of Minzdrav of Russia</aff><aff id="aff-3">The Federal State Budget Scientific Institution “The N. F. Izmerov Research Institute of occupational medicine” of the Russian Academy of Sciences</aff><aff id="aff-4">The Federal State Budget Educational Institution of Higher Education “The Yaroslav the Sage Novgorod State University”</aff><aff id="aff-5">The Federal State Budget Educational Institution of Higher Education “The Kuban State Medical University”</aff><pub-date date-type="epub" iso-8601-date="2019-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2019</year></pub-date><volume>27</volume><issue>5</issue><fpage>796</fpage><lpage>802</lpage><history><pub-date date-type="received" iso-8601-date="2021-04-06"><day>06</day><month>04</month><year>2021</year></pub-date></history><permissions><copyright-statement>Copyright © 2019,</copyright-statement><copyright-year>2019</copyright-year></permissions><abstract>The characteristic feature of molecular medicine as medicine based on molecular structure of human genome data, is its individual character. It is focused on correcting pathological process in specific individual considering unique characteristics of its genome. The other most important feature is its expressed preventive direction. The complete genome information can be obtained well before the onset of disease. The appropriate preventive measures can completely eliminate or significantly prevent development of severe disease. The establishment of gene network of every multi-factorial disease, identification of central genes and genes-modifiers in it, analysis of association of their alleles with disease, development on this basis of set of preventive measures for specific patient constitute conceptual and methodological basis of predictive medicine.As a result of the examination, information can be obtained concerning particular risk of disease development. The physician, considering the results of molecular genetic analysis, elaborates tactics of pathogenetically justified preventive therapy, i.e. corrects congenital metabolic defect.</abstract><kwd-group xml:lang="en"><kwd>metabolic syndrome</kwd><kwd>pr-clinical genome diagnostics</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>метаболический синдром</kwd><kwd>доклиническая геномная диагностика</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Samson S. L., Garber A. J. Metabolic syndrome. Endocrinol. Metab. Clin. North. Am. 2014;43(1):1-23.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Kaur J. A comprehensive Review on Metabolic Syndrome. Cardiol. Res. Pract. 2014. doi: 10.1155/2014/943162</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Procopciuc L., Popescu T., Jebeleanu G., Pop D., Zdrenghea D. Essential Arterial Hypertesion and Polymorphismof Angiotensinogen M235T Gene. J. Cell. Mol. Med. 2002;6(2):245-50.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Azizi M., Hallouin M.-C., Jeunemaitre X., Guyene T. T., Ménard J. Influence of the M235T Polymorphism of Human Angiotensinogen (AGT) on Plasma AGT and Renin Concentrations After Ethinylestradiol Administration. J. Clin. Endocrinol. Metab. 2000;85(11):4331-7.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Zhou A., Carrell R. W., Murphy M. P., Wei Z., Yan Y., Stanley P. L. D., Stein P. E., Broughton Pipkin F., Read R. J. A Redox Switch in Angiotensinogen Modulates Angiotensin Release. Nature. 2010;468(7320):108-11.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Danesh J. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA. 2005;294(14):1799-809.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Mannila M. N. Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction. Thromb. Haemost. 2005;93(3):570-7.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Casas J. P., Hingorani A. D., Bautista L. E., Sharma P. Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch. Neurol. 2004;61(11):1652-61.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Kathiresan S. Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. Arterioscler. Thromb. Vasc. Biol. 2006;26(6):1405-12.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Lusis A. J., Fogelman A. M., Fonarow G. C. Genetic basis of atherosclerosis. II. Clinical implications. Circulation. 2004;110:2066-71.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Богова О. Т., Чукаева И. И. Инфаркт миокарда. Воспаление и прогноз. Российский кардиологический журнал. 2003;(4):18-23.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Gabriel A. S., Ahnve S., Wretlind B., Martinsson A. IL-6 and IL-1 receptor antagonist in stable angina pectoris and relation ofIL-6 to clinical findings in acute myocardial infarction. J. Intern. Med. 2000;248:61-6.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Crea F., Biasucci L. M., Buffon A., Liuzzo G., Monaco C., Caligiuri G., Kol A., Sperti G., Cianflone D., Maseri A. Role of inflammation in the pathogenesis of unstable coronary artery disease. Am. J. Cardiol. 1997;80:10-6.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Brull D. J., Montgomery H. E., Sanders J., Dhamrait S., Luong L., Rumley A., Lowe G. D. O., Humphries S. E. Atherosclerosis and Lipoproteins Interleukin-6 Gene -174 G &gt; C and -572 G &gt; C Promoter Polymorphisms Are Strong Predictors of Plasma Interleukin-6 Levels After Coronary Artery Bypass Surgery. Arterioscler. Thromb. Vasc. Biol. 2001;21:1458-63.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Henningsson S., Håkansson A., Westberg L., Baghaei F., Rosmond R., Holm G., Ekman A., Nissbrandt H., Eriksson E. Interleukin-6 Gene Polymorphism -174 G/C Influences Plasma Lipid Levels in Women. Obesity. 2006;14(11):1868-73.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Humphries S. E., Luong L. A., Ogg M. S., Hawe E., Miller G. J. The interleukin-6 - 174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur. Heart J. 2001;22:2243-52.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Basso F., Lowe G. D. O., Rumley A., McMahon A. D., Humphries S. E. Interleukin-6 - 174 G &gt; C Polymorphism and Risk of Coronary Heart Disease in West of Scotland Coronary Prevention Study (WOSCOPS), on behalf of the WOSCOPS Group. Arterioscler. Thromb. Vasc. Biol. 2002;22:599-604.</mixed-citation></ref></ref-list></back></article>
