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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Problems of Social Hygiene, Public Health and History of Medicine</journal-id><journal-title-group><journal-title>Problems of Social Hygiene, Public Health and History of Medicine</journal-title></journal-title-group><issn publication-format="print">0869-866X</issn><issn publication-format="electronic">2412-2106</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1704</article-id><article-id pub-id-type="doi">10.32687/0869-866X-2025-33-3-494-501</article-id><article-categories><subj-group subj-group-type="heading"><subject>Научная статья</subject></subj-group></article-categories><title-group><article-title>NUTRITION MANAGEMENT FOR COGNITIVE DISORDERS AND DEMENTIA (OVERVIEW)</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Blinkova</surname><given-names>L. N.</given-names></name><email></email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Yakushin</surname><given-names>M. A.</given-names></name><email></email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Karpova</surname><given-names>O. V.</given-names></name><email></email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia</aff><pub-date date-type="epub" iso-8601-date="2025-06-29" publication-format="electronic"><day>29</day><month>06</month><year>2025</year></pub-date><volume>33</volume><issue>3</issue><fpage>494</fpage><lpage>501</lpage><history><pub-date date-type="received" iso-8601-date="2025-06-30"><day>30</day><month>06</month><year>2025</year></pub-date></history><permissions><copyright-statement>Copyright © 2025,</copyright-statement><copyright-year>2025</copyright-year></permissions><abstract>The current trend of increasing life expectancy and aging of the world's population is accompanied by the emergence of a global problem associated with a doubling of patients with «senile dementia» every 20 years. The concept of age-associated forms of cognitive disorders (vascular dementia, Alzheimer's, Parkinson's, etc.) is based on the provisions of the effects of unhealthy lifestyle and nutrition habits, family history, involutive metabolic processes, pathological complications of diseasesand their comorbidity. A literature search of systematic reviews, clinical research reports on the publication type «meta-analysis» and in the Medline system revealed that timely correction of negative PH, in particular the use of herodietics, helps to reduce/slow down the development of vascular dementia and cognitive disorders.</abstract><kwd-group xml:lang="en"><kwd>cognitive disorders, dementia, geroprotective nutrition, herodietics, biologically active substances, antioxidants</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>когнитивные расстройства</kwd><kwd>деменция</kwd><kwd>геропротективное питание</kwd><kwd>геродиетика</kwd><kwd>биологически активные вещества</kwd><kwd>антиоксиданты.</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Якушин М. А., Карпова О. В. МИС «Деменция». Проблемы геронауки: АНО «ОСО ИТЕМ». 2023;47:280-1.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Парфенов В. А., Захаров В. В., Преображенская И. С. Когнитивные расстройства. М.: Группа Ремедиум; 2014. С. 1-106.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Кишкун А. А. Биологический возраст и старение: возможности определения и пути коррекции: Руководство для врачей. М.: ГЭОТАР-Медиа. 2008. С. 62-3.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Блинкова Л. Н. Организационные аспекты питания пожилых людей. Вопросы питания. 2014;83(53):13.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Статевич Н. Ю., Якушин М. А., Шарошина К. Б. и др. Распространенность старческой астении и анализ коморбидной патологии у лиц старше 60 лет (анализ научных публикаций). Вестник медицинского стоматологического института. 2023;(4):29-30.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Dalal R., McGee R. G., Riordan S. M., et al. Probiotics for people with hepatic encephalopathy. Cochrane Database Syst Rev. 2017;2:CD008716.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Valabhji J., Gorton T., Barron E., Safazadeh S., Earnshaw F., Helm C., et al. Early findings from the NHS Type 2 Diabetes Path to Remission Programme: a prospective evaluation of real-world implementation. Lancet Diabetes Endocrinol. 2024;12(9):612-3.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Приказ Минздравсоцразвития России от 05.08.2003 г. №330 «О мерах по совершенствованию лечебного питания в лечебно-профилактических учреждениях РФ» (ред. 24.11.2016).</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Swaminathan M., Ellul M. A., Cross T. J. Hepatic encephalopathy: current challenges and future prospects. Hepat. Med. 2018 Mar 22;10:1-11. doi: 10.2147/HMER.S118964</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Williamson J. D., Pajewski N. M., Auchus A. P. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial. JAMA. 2019;321(6):553-61.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Kornerup L. S., Gluud L. L., Vilstrup H., Dam G. Update on the Therapeutic Management of Hepatic Encephalopathy. Curr. Gastroenterol. Rep. 2018 Apr 11;20(5):21. doi: 10.1007/s11894-018-0627-8</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Andrews V., Zammit G., O’Leary F. Dietary pattern, food, and nutritional supplement effects on cognitive outcomes in mild cognitive impairment: a systematic review of previous reviews. Nutr. Rev. 2023;81(11):1462-89.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Del Parigi A., Panza F., Capurso C., Solfrizzi V. Nutritional factors, cognitive decline, and dementia. Brain Res. Bull. 2006;69(1):1-19.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Chandler M. J., Parks A. C., Marsiske M., et al. Everyday Impact of Cognitive Interventions in Mild Cognitive Impairment: a Systematic Review and Meta-Analysis. Neuropsychol. Rev. 2016;26(3):225-51.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Hill N. T., Mowszowski L., Naismith S. L., et al. Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis. Am. J. Psychiatry. 2017;174(4):329-40.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Singh B., Parsaik A. K., Mielke M. M., et al. Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis. J. Alzheimers Dis. 2014;39(2):271-82.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Tsivgoulis G., Judd S., Letter A. J., et al. Adherence to a Mediterranean diet and risk of incident cognitive impairment. Neurology. 2013;80(18):1684-92.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Гринюк В. В. Эволюция нелекарственной терапии когнитивных нарушений. Поведенческая неврология. 2024;(1):44-51.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Barnes L. L., Klodian D., Liu X., et al. Trial of the MIND diet for prevention of cognitive decline in older persons. N. Engl. J. Med. 2023;389:602-11.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>García-Casares N., Gallego Fuentes P., Barbancho M. Á., et al. Alzheimer’s disease, mild cognitive impairmentand mediterranean diet. A systematic review and doseresponse meta-analysis. J. Clin. Med. 2021;10(20):4642.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Ballarini T., van Lent D. M., Brunner J., et al. Mediterranean diet, Alzheimer disease biomarkers and brain atrophy in old age. Neurology. 2021;96:e2920-e2932.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Gu Y., Luchsinger J. A., Stern Y., et al. Mediterranean Diet, Inflammatory and Metabolic Biomarkers, and Risk of AlzheimerХs Disease. J. Alzheimer Dis. 2010;22(2):483-92.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Jeszka-Skowron M., Zgoła-Grzekowiak A., Grzekowiak T. Analytical methods applied for the characterization and the determination of bioactive compounds in coffee. Eur. Food Res. Technol. 2015;240:19-31.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Liu Q.-P., Wu Y. F., Cheng H. Y., et al. Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and-metaanalysis of prospective cohort studies. Nutrition. 2016;32:628-36.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Сиволап Ю. П., Дамулин И. В. Кофеин: полезное психоактивное вещество? Вопросы диетологии. 2017;7(1):42-6.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Camandola S., Plick N., Mattson M. P. Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease. Neurochem. Res. 2019 Jan;44(1):214-27. doi: 10.1007/s11064-018-2492-0</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Colombo R., Papetti A. An outlook on the role of decaffeinated coffee in neurodegenerative diseases. Crit. Rev. Food Sci. Nutr. 2020;60(5):760-79. doi: 10.1080/10408398.2018.1550384. Epub 2019 Jan 7.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Nabbi-Schroeter D., Elmenhorst D., Oskamp A., Laskowski S., Bauer A., Kroll T. Effects of Long-Term Caffeine Consumption on the Adenosine A1 Receptor in the Rat Brain: an In Vivo PET Study with [18F]CPFPX. Mol. Imaging Biol. 2018 Apr;20(2):284-91.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Cho B. H., Choi S. M., Kim J. T., Kim B. C. Association of coffee consumption and non-motor symptoms in drug-naïve, early-stage Parkinson's disease. Parkinsonism Relat. Disord. 2018 May:50:42-7. doi: 10.1016/j.parkreldis.2018.02.016. Epub 2018 Feb 9.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Scheperjans F., Pekkonen E., Kaakkola S., Auvinen P. Linking Smoking, Coffee, Urate, and Parkinson's Disease — A Role for Gut Microbiota? J. Parkinsons Dis. 2015;5(2):255-62.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Зайцева О. Е. Должны потребители кофеин-содержащих напитков знать фармакокинетику кофеина? Фундаментальные исследования. 2015;(1-5):946-52.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Щербакова А. С., Ткач В. В., Ткач А. В. Влияние дефицит витамина Д на течение нейродегенеративных заболеваний. Modern Science. 2021;1(2):250-4.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Cui X., Pelekanos M., Burne T. H., et al. Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon. Neurosci. Lett. 2010;486(3):220-3.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Cui X., Pelekanos M., Liu P. Y., et al. The vitamin D receptor in dopamine neurons; its presence in human substantianigra and its ontogenesis in rat midbrain. Neuroscience. 2013;236:77-87.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Moore C., Murphy M. M., Keast D. R., et al. Vitamin D intake in the United States. J. Am. Dietet. Assoc. 2004;104(6):980-3.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Kesby J. P., Cui X., O’Loan J., et al. Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats. Psychopharmacology. 2010;208(1):159-68.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Jayedi A., Rashidy-Pour A., Shab-Bidar S. Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response. Nutrit. Neurosci. 2019;22(11):750-9.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Annweiler C. Vitamin D in dementia prevention. Ann. N. Y. Acad. Sci. 2016;1367(1):57-63.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Llewellyn D. J., Lang I. A., Langa K. M., Muniz-Terrera G., Phillips C. L., Cherubini A., Ferrucci L., Melzer D. Vitamin D and risk of cognitive decline in elderly persons. Arch. Intern. Med. 2010;170(13):1135-41.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Alsharidah M., Murtaza A., Alsharidah G. M., Bashir S. Fasting in Ramadan affects cognitive and physiological function in normal subjects (pilot study). Neurosci. Med. 2016;7:60-5.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Moberg P. J., Turetsky B. I. Scent of a disorder: olfactory functioning in schizophrenia. Curr. Psychiatry Rep. 2003;5:311-31.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Crichton G. E., Bryan J., Murphy K. J. Dietary antioxidants, cognitive function and dementia — a systematic review. Plant. Foods Hum. Nutr. 2013;68:279-92.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Vlachos G. S., Scarmeas N. Dietary interventions in mild cognitive impairment and dementia. Dialogues Clin. Neurosci. 2019;21(1):69-82.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Logroscino G., Mayeux R. Diet and Parkinson’s disease. Neurology. 1997;49(2):310-1.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Методические рекомендации МР 2.3.1.1915-04 «Рекомендуемые уровни потребления пищевых и биологических веществ». В. А. Тутельян, Г. Г. Онищенко, А. В. Скальный и др. М.; 2004. 36 с.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Larrieu S., Letenneur L., Helmer C., et al. Nutritional factors and risk of incident dementia inthe PAQUID longitudinal cohort. J. Nutr. Health Aging. 2004;8:150-4.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Johnson E. J. Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutr. Rev. 2014;72:605-12.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Liu C. B., Wang R., Yi Y. F., et al. Lycopene mitigates β-amyloid induced inflammatory response and inhibits NF-κB signaling at the choroid plexus in early stages of Alzheimer’s disease rats. J. Nutr. Biochem. 2018;53:66-71.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Wang J., Li L., Wang Z., et al. Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress. J. Nutr. Biochem. 2018;56:16-25.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Cattane A., Cattan N., Galluzzi S., et al. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol. Aging. 2017;49:60-8. doi: 10.1016/j.neurobiolaging.2016.08.019</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Gu S. L., Gong Y., Zhang J., et al. Effect of the Short-Term Use of Fluoroquinolone and β-Lactam Antibiotics on Mouse Gut Microbiota. Infect. Drug Resist. 2020;13:4547-58.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Tian J., Lu Y., Zhang H., et al. Gamma-aminobutyric Acid Inhibits T Cell Autoimmunity and the Development of Inflammatory Responses in a Mouse Type 1 Diabetes Model. J Immunol. 2004;173(8):5298-304. doi: 10.4049/jimmunol.173.8.5298</mixed-citation></ref></ref-list></back></article>
