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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Problems of Social Hygiene, Public Health and History of Medicine</journal-id><journal-title-group><journal-title>Problems of Social Hygiene, Public Health and History of Medicine</journal-title></journal-title-group><issn publication-format="print">0869-866X</issn><issn publication-format="electronic">2412-2106</issn><publisher><publisher-name>Joint-Stock Company Chicot</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1454</article-id><article-id pub-id-type="doi">10.32687/0869-866X-2024-32-2-203-207</article-id><article-categories><subj-group subj-group-type="heading"><subject>Неопределен</subject></subj-group></article-categories><title-group><article-title>The analysis of dynamics of indicator of mortality of population of the Siberian Federal Okrug resulted from toxic impact of alcohol in 2011–2020</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Sabaev</surname><given-names>A V</given-names></name><email>alesabaev@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Pasechnik</surname><given-names>O A</given-names></name><email>opasechnik@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">The Federal State Budget Educational Institution of Higher Education “The Omsk State Medical University” of Minzdrav of Russia, 644099, Omsk, Russia</aff><pub-date date-type="epub" iso-8601-date="2024-04-18" publication-format="electronic"><day>18</day><month>04</month><year>2024</year></pub-date><volume>32</volume><issue>2</issue><history><pub-date date-type="received" iso-8601-date="2025-04-21"><day>21</day><month>04</month><year>2025</year></pub-date><pub-date date-type="accepted" iso-8601-date="2025-04-21"><day>21</day><month>04</month><year>2025</year></pub-date></history><permissions><copyright-statement>Copyright © 2025,</copyright-statement><copyright-year>2025</copyright-year></permissions><abstract>&lt;p&gt;The purpose of the study is to investigate dynamics of mortality of population of the Siberian Federal Okrug resulted from toxic impact of alcohol in 20112020 and to comparatively analyze mortality of population of the regions of the Siberian Federal Okrug with general Okrug values.&lt;br /&gt;The study uses statistical data of the Federal State Statistics Service of the Russian Federation. The analysis was applied to mortality of population of the Russian Federation, the Siberian Federal Okrug and the regions of the Siberian Federal Okrug (the Republic of Altai, the Republic of Tuva, the Republic of Khakassia, the Altai Kray, the Krasnoyarsk Kray, Irkutsk, Kemerovo, Novosibirsk, Omsk and Tomsk Oblast) resulted from toxic impact of alcohol. The comparative analysis of regional and general Okrug indicators of mortality was implemented. The statistical processing of data included common methods of calculating extensive and intensive indicators, indicator average error and evaluation of reliability of differences. It was established that in 20112020, mortality of population of the Siberian Federal Okrug resulted from toxic impact of alcohol decreased by 3.3 times. The decrease of mortality of the population was registered in all regions of the Siberian Federal Okrug. The fastest decreasing of mortality of population occurred in the Altai Kray (7.7 times), the Republic of Tuva (7.0 times), the Krasnoyarsk Kray (6.4 times). The investigation of dynamics of mortality of population in the regions of the Siberian Federal Okrug resulted from toxic impact of alcohol permits to identify characteristics of toxicological situation at the regional level and to determine strategic directions of the regional policy of chemical safety and population health protection.&lt;/p&gt;</abstract><kwd-group xml:lang="en"><kwd>mortality</kwd><kwd>population</kwd><kwd>toxic impact</kwd><kwd>alcohol</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>смертность населения</kwd><kwd>токсическое воздействие алкоголя</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Narcology: national guidance [Narkologiya: nacional'noe rukovodstvo]. Eds N. N. Ivanets, I. P. Anohina, V. A. Vinnikova. 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