Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot140810.32687/0869-866X-2025-33-1-48-52НеопределенThe methodological approaches to evaluation of economical efficiency of application of HPV-testing and cytological examination under provision of medical care on “Obstetrics and Gynecology” profileOlkovI Ginfo@bfrazvitie.ruGrishinaN Kotdel-77@mail.ruLuzanovO Aquicksilvernov789@gmail.comN. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia160420253311604202516042025Copyright © 2025,2025<p>The article presents comprehensive methodology to assess economic efficiency of application of HPV-testing and cytological examination under provision of medical care on Obstetrics and Gynecology profile. The implementation of proposed methodological approaches permitted to calculate costs and value of result of study using HPV-screening and common cytology, i.e. their economic efficiency. The higher (up to 25%) economic efficiency of HPV-screening was established.</p>1.Wentzensen N., Arbyn M., Berkhof J., Bower M., Canfell K., Einstein M., Farley C., Monsonego J., Franceschi S. Eurogin 2016 Roadmap: how HPV knowledge is changing screening practice. Int. J. Cancer. 2017;140(10):2192–200. doi: 10.1002/ijc.305792.Ronco G., Dillner J., Elfström K. M., Tunesi S., Snijders P. J., Arbyn M., Kitchener H., Segnan N., Gilham C., Giorgi-Rossi P., Berkhof J., Peto J., Meijer C. J. Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials. Lancet. 2014;383:524–32. doi: 10.1016/S0140-6736(13)62218-73.Cuschieri K., Ronco G., Lorincz A., Smith L., Ogilvie G., Mirabello L., Carozzi F., Cubie H., Wentzensen N., Snijders P., Arbyn M., Monsonego J., Franceschi S. Eurogin 2017 Roadmap: Triage strategies for the management of HPV-positive women in cervical screening programs. Int. J. Cancer. 2018;143:4:735–45. doi: 10.1002/ijc.312614.Arbyn M., Verdoodt F., Snijders P. J., Verhoef V. M., Suonio E., Dillner L., Minozzi S., Bellisario C., Banzi R., Zhao F. H., Hillemanns P., Anttila A. Accuracy of human papillomavirus testing on selfcollected versus clinician-collected samples: a meta-analysis. Lancet Oncol. 2014;15:172–83. doi: 10.1016/S1470-2045(13)70570-95.Verdoodt F., Jentschke M., Hillemanns P., Racey C. S., Snijders P. J., Arbyn M. Reaching women who do not participate in the regular cervical cancer screening programme by offering self-sampling kits: a systematic review and meta-analysis of randomised trials. Eur. J. Cancer. 2015;51:2375–85. doi: 10.1016/j.ejca.2015.07.0066.Guan P., Howell-Jones R., Li N., Bruni L., de Sanjosé S., Franceschi S., Clifford G. M. Human papillomavirus types in 115,789 HPV-positive women: a meta-analysis from cervical infection to cancer. Int. J. Cancer. 2012;131:2349–59. doi: 10.1002/ijc.274857.Gilham C., Sargent A., Kitchener H. C., Peto J. HPV testing compared with routine cytology in cervical screening: long-term follow-up of ARTISTIC RCT. Health Technol. Assess. 2019;23(28):1—44. doi: 10.3310/hta232808.Belokrinitskaya T. E., Frolova N. I., Turanova O. V., Shemyakina K. N., Pletneva V. A., Sambueva N. B., Mal’tseva E. E. Effectiveness and acceptability of examination for human papillomavirus with independent and medical sampling of vaginal discharge. Akusherstvo i ginekologiya. 2017;(2):97–105. doi: 10.18565/aig.2017.2.97-105 (in Russian).9.Arbyn M., Castle P. E., Schiffman M., Wentzensen N., Heckman-Stoddard B., Sahasrabuddhe V. V. Meta-analysis of agreement/concordance statistics in studies comparing self-vs clinician-collected samples for HPV testing in cervical cancer screening. Int. J. Cancer. 2022;151(2):308–12. doi: 10.1002/ijc.3396710.Cho H. W., Shim S. R., Lee J. K., Hong J. H. Accuracy of human papillomavirus tests on self-collected urine versus clinician-collected samples for the detection of cervical precancer: a systematic review and meta-analysis. J. Gynecol. Oncol. 2022;33(1):e4. doi: 10.3802/jgo.2022.33.e411.Klinyshkova T. V. Cervical screening strategies: a modern perspective. Russian Bulletin of Obstetrician-Gynecologist. 2023;23(4):20–6. doi: 10.17116/rosakush20232304120 (in Russian).