Problems of Social Hygiene, Public Health and History of MedicineProblems of Social Hygiene, Public Health and History of Medicine0869-866X2412-2106Joint-Stock Company Chicot105710.32687/0869-866X-2022-30-s1-1038-1043Научная статьяDIGITAL THERAPY TECHNOLOGIES (LITERATURE REVIEW)KravchukA. A.-AksenovaE. I.-KamyninaN. N.kamyninann@zdrav.mos.ruResearch Institute for Healthcare Organization and Medical Management of Moscow Healthcare DepartmentPeoples’ Friendship University of Russia1511202230s11038104317112022Copyright © 2022,2022This article presents an analysis of international experience in the implementation of digital therapeutics technologies in health care. The features of digital therapeutics products: their distinction from digital health products and digital medicine are highlighted. An analysis of the global market for digital therapeutics is presented. The aspects of regulation of digital therapeutics and the barriers to its implementation are presented. The importance of digital therapeutics for the transition of health systems to a value-based management model is discussed.digital therapeuticsreviewhealthcaremedical technologyцифровая терапияобзорздравоохранениемедицинские технологии[Goldsack J., Coder M., Fitzgerald C. et al. Digital Health, digital medicine, digital therapeutics (DTx): what’s the difference. URL: https://www.dimesociety.org/digital-health-digital-medicine-digital-therapeutics-dtx-whats-the-difference (дата обращения: 16.05.2022).][Будущее цифровых систем здравоохранения в Европейском регионе: oтчет о проведении симпозиума ВОЗ (Копенгаген, Дания, 6-8 февраля 2019 г.). URL: https://apps.who.int/iris/bitstream/handle/10665/330370/9789289059985-rus.pdf (дата обращения: 16.05.2022).][Dang A., Arora D., Rane P. Role of digital therapeutics and the changing future of healthcare //j. Family Med. Prim. Care. 2020. Vol. 9, N 5. P. 2207-2213. DOI: 10.4103/jfmpc.jfmpc_105_20][Digital Therapeutics Market Forecast to 2028 - COVID-19 impact and global analysis by application and distribution channel. URL: https://www.researchandmarkets.com/research/k3bkcf/global_8_94_bn?w=12 (дата обращения: 16.05.2022).][Chung J. Y. Digital therapeutics and clinical pharmacology // Transl. Clin. Pharmacol. 2019. Vol. 27, N 1. P. 6-11. DOI: 10.12793/tcp.2019.27.1.6][Advisory firm «MarketsandMarkets™ Research Private Ltd.». Digital therapeutics (DTx) market by application (prediabetes, nutrition, care, diabetes, CVD, CNS, CRD, MSD, GI, substance abuse, rehabilitation), sales channel (B2C, patient, caregiver, B2B, providers, payer, employer, pharma) (2022-2026). URL: https://www.marketsandmarkets.com/Market-Reports/digital-therapeutics-market-51646724.html (дата обращения: 16.05.2022).][Мarket intelligence and advisory firm «Mordor Intelligence». Digital therapeutic devices market - growth, trends, COVID-19 impact and forecasts (2022-2027). URL: https://www.mordorintelligence.com/ru/industry-reports/digital-therapeutic-devices-market (дата обращения: 16.05.2022).][Deloitte Touche Tohmatsu. Digital therapeutics catalysing the future of health. URL: https://www2.deloitte.com/content/dam/Deloitte/ch/Documents/life-sciences-health-care/deloitte-ch-en-lshc-digital-therapeutics.pdf (дата обращения: 16.05.2022).][Recchia G., Capuano D. M., Mistri N., Verna R. Digital therapeutics - what they are, what they will be // Acta Sci. Med. Sci. 2020. Vol. 4, N 3. P. 134-142. DOI: 10.31080/ASMS.2020.04.0575][Digital Therapeutics Alliance. URL: http://dtxalliance.org (дата обращения: 16.05.2022).][Sverdlov О., van Dam J., Hannesdottir K., Thornton-Wells T. Therapeutics: an integral component of digital innovation in drug development // Clin. Pharmacol. Ther. 2018. Vol. 104, N 1. P. 72-80. DOI: 10.1002/cpt.1036][Ларина О. Д., Орлова О. С., Дегтярева М. В. Цифровая терапия - инновационное направление логопедической работы // Специальное образование. 2021. № 3. C. 115-139.][Williams M. G., Stott R., Bromwich N. et al. Determinants of and barriers to adoption of digital therapeutics for mental health at scale in the NHS // BMJ Innovations. 2020. Vol. 6. P. 92-98. DOI: 10.1136/bmjinnov-2019-000384][Research and advisory company of Allied Analytics LLP. Digital therapeutics market by application (diabetes, obesity, cardio vascular diseases (CVD), central nervous system (CNS) disease, respiratory diseases, smoking cessation, gastrointestinal disorders, and others), product type (software, and devices), and sales channel (business-to-business and business-to-consumers): global opportunity analysis and industry forecast, 2021-2030. URL: https://www.alliedmarketresearch.com/digital-therapeutics-market (дата обращения: 16.05.2022).][International Medical Device Regulators Forum. URL: https://www.imdrf.org/about (дата обращения: 16.05.2022).][Холовня-Волоскова М. Э., Толкушин А. Г., Корнилова Е. Б., Завьялов А. А. Сравнительная характеристика видов оценки медицинских технологий // Проблемы социальной гигиены, здравоохранения и истории медицины. 2020. Т. 28, № S2. С. 1168-1175. DOI: 10.32687/0869-866X-2020-28-s2-1168-1175][Parcher B., Coder M. Decision makers need an approach to determine digital therapeutic product quality, access, and appropriate use //j. Manag. Care Spec. Pharm. 2021. Vol. 27, N 4. P. 536-538.][The Growing Value of Digital Health. Parsipanny; 2017. P. 76. URL: https://regresearchnetwork.org/wp-content/uploads/the-growing-value-of-digital-health.pdf (дата обращения: 16.05.2022).][Grigolo S. et al. The patient, digital health and digital therapeutics // Tendenze nuove, Numero Speciale 4 2021; 161-178. URL: https://www.tendenzenuove.it/2021/07/29/the-patient-digital-health-and-digital-therapeutics (дата обращения: 16.05.2022).][Hong J. S., Wasden C., Han D. H.Introduction of digital therapeutics // Comput. Methods Programs Biomed. 2021. Vol. 209. P. 106319. DOI: 10.1016/j.cmpb.2021.106319][Lovett L. Digital therapeutics may not cause toxicity, but they’re not entirely without risk. URL: https://www.mobihealthnews.com/news/north-america/digital-therapeutics-may-not-cause-toxicity-theyre-not-entirely-without-risk (дата обращения: 16.05.2022).][Ковальский В. Цифровое здравоохранение - где в нем бизнес, а где мыльный пузырь? URL: https://www.forbes.ru/tehnologii/339101-cifrovoe-zdravoohranenie-gde-v-nem-biznes-gde-mylnyy-puzyr (дата обращения: 16.05.2022).][Joyce M., Leclerc O., Westhues K., Xue H. Digital therapeutics: рreparing for takeoff. URL: https://www.mckinsey.com/industries/life-sciences/our-insights/digital-therapeutics-preparing-for-takeoff (дата обращения: 16.05.2022).][Khirasaria R., Singh V., Batta A. Exploring digital therapeutics: the next paradigm of modern health-care industry // Perspect. Clin. Res. 2020. Vol. 11, N 2. P. 54-58. DOI: 10.4103/picr.PICR_89_19][Rastegayeva I. The rise of digital therapeutics. URL: https://blogs.3ds.com/northamerica/the-rise-of-digital-therapeutics (дата обращения: 16.05.2022).][Wiederhold B. K. Data-driven digital therapeutics: the path forward // Cyberpsychology, Behavior, and Social Networking. 2021. Vol. 24, N 10. P. 631-632. DOI: 10.1089/cyber.2021.29227.editorial][Abbadessa G., Brigo F., Clerico M. et al. Digital therapeutics in neurology //j. Neurol. 2021. Vol. 269, N 13. P. 1-16. DOI: 10.1007/s00415-021-10608-4][Ferguson C., Hickman L., Wright R. et al. Preparing nurses to be prescribers of digital therapeutics // Contemp. Nurse. 2018. Vol. 54, N 4-5. P. 345-349. DOI: 10.1080/10376178.2018.1486943]